ArticleJournal of bacteriology2003
Hemin binding, functional expression, and complementation analysis of Pap 31 from Bartonella henselae.
Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Sneaky tactics: Ingenious immune evasion mechanisms ofVirulence · 2024Review
- Blood Supplementation Enhances Bartonella henselae Growth and Molecular Detection of Bacterial DNA in Liquid Culture.Microbiology spectrum · 2023Article
- Article
- Carrion's disease: more than a neglected disease.Parasites & vectors · 2019Review
- Molecular Mechanisms ofFrontiers in cellular and infection microbiology · 2018Review
- Dynamics of Co-Infection with Bartonella henselae Genotypes I and II in Naturally Infected Cats: Implications for Feline Vaccine Development.Microbial ecology · 2017Article
- Bartonella Species, an Emerging Cause of Blood-Culture-Negative Endocarditis.Clinical microbiology reviews · 2017Review
- Development of a serum-free liquid medium for Bartonella species.Folia microbiologica · 2016Article
- The Detection of Hemin-Binding Proteins in Riemerella anatipestifer CH-1.Current microbiology · 2016Article
- Managing iron supply during the infection cycle of a flea borne pathogen, Bartonella henselae.Frontiers in cellular and infection microbiology · 2013Review
- Hemin binding protein C is found in outer membrane vesicles and protects Bartonella henselae against toxic concentrations of hemin.Infection and immunity · 2012Article
- Strategies of exploitation of mammalian reservoirs by Bartonella species.Veterinary research · 2012Review
- Intruders below the radar: molecular pathogenesis of Bartonella spp.Clinical microbiology reviews · 2012Review
- Heme binding proteins of Bartonella henselae are required when undergoing oxidative stress during cell and flea invasion.PloS one · 2012Article
- Pestilence, persistence and pathogenicity: infection strategies of Bartonella.Future microbiology · 2009Review
- Function, regulation, and transcriptional organization of the hemin utilization locus of Bartonella quintana.Infection and immunity · 2009Article
- Analysis of a novel insect cell culture medium-based growth medium for Bartonella species.Applied and environmental microbiology · 2008Article
- Mixed infections, cryptic diversity, and vector-borne pathogens: evidence from Polygenis fleas and Bartonella species.Applied and environmental microbiology · 2007Article
- Transcriptional regulation of the heme binding protein gene family of Bartonella quintana is accomplished by a novel promoter element and iron response regulator.Infection and immunity · 2007Article
- Environmental signals generate a differential and coordinated expression of the heme receptor gene family of Bartonella quintana.Infection and immunity · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth of Bartonella henselae is strongly heme dependent, and B. henselae is unable to synthesize heme itself. At least five outer membrane-associated proteins from B. henselae bind hemin, including the 31-kDa protein designated Pap31. The gene of this protein was heterologously expressed in Escherichia coli M15(pREP4) and detected with monoclonal antibodies in the outer membrane fraction. Complementation of the hemA-deficient mutant E. coli K-12 EB53 (aroB tsx malT hemA) with pap31 demonstrated that this protein is involved in heme acquisition and may be an important virulence factor in the pathogenesis of B. henselae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.