ArticleJournal of bacteriology2003
Structural model for 12-helix transporters belonging to the major facilitator superfamily.
Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
42 citing papers in PubMed.
- Plant SUT Sucrose Transporters: Structure, Evolution and Biological Functions.Current protein & peptide science · 2026Review
- Phosphate TransporterPlants (Basel, Switzerland) · 2023Article
- Ins and Outs of Rocker Switch Mechanism in Major Facilitator Superfamily of Transporters.Membranes · 2023Review
- Plant SWEET Family of Sugar Transporters: Structure, Evolution and Biological Functions.Biomolecules · 2022Review
- Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria.Chemical reviews · 2021Review
- VGLUT substrates and inhibitors: A computational viewpoint.Biochimica et biophysica acta. Biomembranes · 2020Review
- Expansion of the Major Facilitator Superfamily (MFS) to include novel transporters as well as transmembrane-acting enzymes.Biochimica et biophysica acta. Biomembranes · 2020Article
- Article
- Critical Roles of Two Hydrophobic Residues within Human Glucose Transporter 9 (hSLC2A9) in Substrate Selectivity and Urate Transport.The Journal of biological chemistry · 2015Article
- Mycobacterium smegmatis MSMEG_3705 encodes a selective major facilitator superfamily efflux pump with multiple roles.Current microbiology · 2015Article
- Multidrug efflux pumps from Enterobacteriaceae, Vibrio cholerae and Staphylococcus aureus bacterial food pathogens.International journal of environmental research and public health · 2015Review
- Identification of molecular hinge points mediating alternating access in the vesicular monoamine transporter VMAT2.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Inverted topologies in membrane proteins: a mini-review.Computational and structural biotechnology journal · 2013Review
- Apo-intermediate in the transport cycle of lactose permease (LacY).Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- MhbT is a specific transporter for 3-hydroxybenzoate uptake by Gram-negative bacteria.Applied and environmental microbiology · 2012Article
- The major facilitator superfamily (MFS) revisited.The FEBS journal · 2012Article
- Biochemical and molecular characterization of the gentisate transporter GenK in Corynebacterium glutamicum.PloS one · 2012Article
- SV2 regulates neurotransmitter release via multiple mechanisms.American journal of physiology. Cell physiology · 2010Article
- Identification of a key residue determining substrate affinity in the yeast glucose transporter Hxt7: a two-dimensional comprehensive study.The Journal of biological chemistry · 2010Article
- Conformational Propensities of Peptides Mimicking Transmembrane Helix 5 and Motif C in Wild-type and Mutant Vesicular Acetylcholine Transporters.ACS chemical neuroscience · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The major facilitator superfamily includes a large collection of evolutionarily related proteins that have been implicated in the transport of a variety of solutes and metabolites across the membranes of organisms ranging from bacteria to humans. We have recently reported the three-dimensional structure, at 6.5 A resolution, of the oxalate transporter, OxlT, a representative member of this superfamily. In the oxalate-bound state, 12 helices surround a central cavity to form a remarkably symmetrical structure that displays a well-defined pseudo twofold axis perpendicular to the plane of the membrane as well as two less pronounced, mutually perpendicular pseudo twofold axes in the plane of the membrane. Here, we combined this structural information with sequence information from other members of this protein family to arrive at models for the arrangement of helices in this superfamily of transport proteins. Our analysis narrows down the number of helix arrangements from about a billion starting possibilities to a single probable model for the relative spatial arrangement for the 12 helices, consistent both with our structural findings and with the majority of previous biochemical studies on members of this superfamily.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.