ArticleBMC evolutionary biology2003
Compensatory mutations cause excess of antagonistic epistasis in RNA secondary structure folding.
Article in BMC evolutionary biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Key Factors That Enable the Pandemic Potential of RNA Viruses and Inter-Species Transmission: A Systematic Review.Viruses · 2021Pooled it
- The coupon collector and the suppressor mutation: estimating the number of compensatory mutations by maximum likelihood.Genetics · 2005Pooled it
- KnotAli: informed energy minimization through the use of evolutionary information.BMC bioinformatics · 2022Article
- Conserved long-range base pairings are associated with pre-mRNA processing of human genes.Nature communications · 2021Article
- Evolution of linkage and genome expansion in protocells: The origin of chromosomes.PLoS genetics · 2020Article
- Recent insights into the genotype-phenotype relationship from massively parallel genetic assays.Evolutionary applications · 2019Review
- Mutation and Epistasis in Influenza Virus Evolution.Viruses · 2018Review
- Negative Epistasis in Experimental RNA Fitness Landscapes.Journal of molecular evolution · 2017Review
- Experimental evolution and the dynamics of adaptation and genome evolution in microbial populations.The ISME journal · 2017Review
- The effects of structure on pre-mRNA processing and stability.Methods (San Diego, Calif.) · 2017Review
- Strong Selection Significantly Increases Epistatic Interactions in the Long-Term Evolution of a Protein.PLoS genetics · 2016Article
- Distribution of mutational fitness effects and of epistasis in the 5' untranslated region of a plant RNA virus.BMC evolutionary biology · 2015Article
- Intramolecular phenotypic capacitance in a modular RNA molecule.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Expected Effect of Deleterious Mutations on Within-Host Adaptation of Pathogens.Journal of virology · 2015Article
- A genotype network reveals homoplastic cycles of convergent evolution in influenza A (H3N2) haemagglutinin.Proceedings. Biological sciences · 2014Article
- The effect of gene overlapping on the rate of RNA virus evolution.Molecular biology and evolution · 2013Article
- Magnitude and sign epistasis among deleterious mutations in a positive-sense plant RNA virus.Heredity · 2012Article
- Interactions between evolutionary processes at high mutation rates.Evolution; international journal of organic evolution · 2012Article
- Impact of epistasis and pleiotropy on evolutionary adaptation.Proceedings. Biological sciences · 2012Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe rate at which fitness declines as an organism's genome accumulates random mutations is an important variable in several evolutionary theories. At an intuitive level, it might seem natural that random mutations should tend to interact synergistically, such that the rate of mean fitness decline accelerates as the number of random mutations is increased. However, in a number of recent studies, a prevalence of antagonistic epistasis (the tendency of multiple mutations to have a mitigating rather than reinforcing effect) has been observed.
resultsWe studied in silico the net amount and form of epistatic interactions in RNA secondary structure folding by measuring the fraction of neutral mutants as a function of mutational distance d. We found a clear prevalence of antagonistic epistasis in RNA secondary structure folding. By relating the fraction of neutral mutants at distance d to the average neutrality at distance d, we showed that this prevalence derives from the existence of many compensatory mutations at larger mutational distances.
conclusionsOur findings imply that the average direction of epistasis in simple fitness landscapes is directly related to the density with which fitness peaks are distributed in these landscapes.
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