ArticleMolecular biology of the cell2003
In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex.
Article in Molecular biology of the cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Rapid poxvirus engineering using CRISPR/Cas9 as a selection tool.Communications biology · 2020Article
- Subunits of human condensins are potential therapeutic targets for cancers.Cell division · 2018Article
- Double-strand break repair-adox: Restoration of suppressed double-strand break repair during mitosis induces genomic instability.Cancer science · 2014Review
- Condensin suppresses recombination and regulates double-strand break processing at the repetitive ribosomal DNA array to ensure proper chromosome segregation during meiosis in budding yeast.Molecular biology of the cell · 2014Article
- Canonical non-homologous end joining in mitosis induces genome instability and is suppressed by M-phase-specific phosphorylation of XRCC4.PLoS genetics · 2014Article
- Inactivation of SMC2 shows a synergistic lethal response in MYCN-amplified neuroblastoma cells.Cell cycle (Georgetown, Tex.) · 2014Article
- Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs.The Journal of experimental medicine · 2012Article
- Structural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4.Molecular and cellular biology · 2009Article
- Involvement of HTLV-I Tax and CREB in aneuploidy: a bioinformatics approach.Retrovirology · 2006Article
- Condensin I interacts with the PARP-1-XRCC1 complex and functions in DNA single-strand break repair.Molecular cell · 2006Article
- The Nse5-Nse6 dimer mediates DNA repair roles of the Smc5-Smc6 complex.Molecular and cellular biology · 2006Article
- Nse1, Nse2, and a novel subunit of the Smc5-Smc6 complex, Nse3, play a crucial role in meiosis.Molecular biology of the cell · 2004Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Several findings have revealed a likely role for DNA ligase IV, and interacting protein XRCC4, in the final steps of mammalian DNA double-strand break repair. Recent evidence suggests that the human DNA ligase IV protein plays a critical role in the maintenance of genomic stability. To identify protein-protein interactions that may shed further light on the molecular mechanisms of DSB repair and the biological roles of human DNA ligase IV, we have used the yeast two-hybrid system in conjunction with traditional biochemical methods. These efforts have resulted in the identification of a physical association between the DNA ligase IV polypeptide and the human condensin subunit known as hCAP-E. The hCAP-E polypeptide, a member of the Structural Maintenance of Chromosomes (SMC) super-family of proteins, coimmunoprecipitates from cell extracts with DNA ligase IV. Immunofluorescence studies reveal colocalization of DNA ligase IV and hCAP-E in the interphase nucleus, whereas mitotic cells display colocalization of both polypeptides on mitotic chromosomes. Strikingly, the XRCC4 protein is excluded from the area of mitotic chromosomes, suggesting the formation of specialized DNA ligase IV complexes subject to cell cycle regulation. We discuss our findings in light of known and hypothesized roles for ligase IV and the condensin complex.
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