ArticleProceedings of the National Academy of Sciences of the United States of America2003
A Saccharomyces cerevisiae mutant with increased virulence.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 102 citations in OpenAlex.
- Conserved signaling modules regulate filamentous growth in fungi: a model for eukaryotic cell differentiation.Genetics · 2024Review
- Post-transcriptional control of fungal cell wall synthesis.Cell surface (Amsterdam, Netherlands) · 2022Article
- Heme Oxygenase-1 (Journal of fungi (Basel, Switzerland) · 2022Article
- SSD1 modifies phenotypes of Elongator mutants.Current genetics · 2020Review
- SSD1 suppresses phenotypes induced by the lack of Elongator-dependent tRNA modifications.PLoS genetics · 2019Article
- An Ssd1 Homolog Impacts Trehalose and Chitin Biosynthesis and Contributes to Virulence in Aspergillus fumigatus.mSphere · 2019Article
- Disruption of gul-1 decreased the culture viscosity and improved protein secretion in the filamentous fungus Neurospora crassa.Microbial cell factories · 2018Article
- Genome-Wide Screen forG3 (Bethesda, Md.) · 2018Article
- Synergistic and antagonistic effects of immunomodulatory drugs on the action of antifungals againstPeerJ · 2018Article
- Lactate signalling regulates fungal β-glucan masking and immune evasion.Nature microbiology · 2016Article
- LncRNAs: Bridging environmental sensing and gene expression.RNA biology · 2016Article
- Whole Genome Analysis of 132 Clinical Saccharomyces cerevisiae Strains Reveals Extensive Ploidy Variation.G3 (Bethesda, Md.) · 2016Article
- The NDR Kinase Cbk1 Downregulates the Transcriptional Repressor Nrg1 through the mRNA-Binding Protein Ssd1 in Candida albicans.Eukaryotic cell · 2015Article
- A Genetic Screen for Saccharomyces cerevisiae Mutants That Fail to Enter Quiescence.G3 (Bethesda, Md.) · 2015Article
- Determination of MICING: a new assay for assessing minimal inhibitory concentration for invasive growth.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Characterization of Cell Wall Proteins in Saccharomyces cerevisiae Clinical Isolates Elucidates Hsp150p in Virulence.PloS one · 2015Article
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- Turbidostat culture of Saccharomyces cerevisiae W303-1A under selective pressure elicited by ethanol selects for mutations in SSD1 and UTH1.FEMS yeast research · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Saccharomyces cerevisiae, bakers' yeast, is not a pathogen in healthy individuals, but is increasingly isolated from immunocompromised patients. The more frequent isolation of S. cerevisiae clinically raises a number of questions concerning the origin, survival, and virulence of this organism in human hosts. Here we compare the virulence of a human isolate, a strain isolated from decaying fruit, and a common laboratory strain in a mouse infection model. We find that the plant isolate is lethal in mice, whereas the laboratory strain is avirulent. A knockout of the SSD1 gene, which alters the composition and cell wall architecture of the yeast cell surface, causes both the clinical and plant isolates to be more virulent in the mouse model of infection. The hypervirulent ssd1 Delta/ssd1 Delta yeast strain is a more potent elicitor of proinflammatory cytokines from macrophages in vitro. Our data suggest that the increased virulence of the mutant strains is a consequence of unique surface characteristics that overstimulate the proinflammatory response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.