ArticleMolecular and cellular biology2003
Cascade of distinct histone modifications during collagenase gene activation.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 89 citations in OpenAlex.
- Article
- Nucleosomes Are Essential for Proper Regulation of a Multigated Promoter in Saccharomyces cerevisiae.Genetics · 2016Article
- O-Linked β-N-acetylglucosamine (O-GlcNAc) Acts as a Glucose Sensor to Epigenetically Regulate the Insulin Gene in Pancreatic Beta Cells.The Journal of biological chemistry · 2016Article
- Deep sequencing reveals novel Set7 networks.Cellular and molecular life sciences : CMLS · 2014Article
- Redox-sensitive gene-regulatory events controlling aberrant matrix metalloproteinase-1 expression.Free radical biology & medicine · 2014Article
- Transcriptional regulation by the Set7 lysine methyltransferase.Epigenetics · 2013Review
- Barriers to transmission of transcriptional noise in a c-fos c-jun pathway.Molecular systems biology · 2013Article
- Chromatin modifications associated with diabetes.Journal of cardiovascular translational research · 2012Review
- Distal interleukin-1β (IL-1β) response element of human matrix metalloproteinase-13 (MMP-13) binds activator protein 1 (AP-1) transcription factors and regulates gene expression.The Journal of biological chemistry · 2012Article
- Redox-control of matrix metalloproteinase-1: a critical link between free radicals, matrix remodeling and degenerative disease.Respiratory physiology & neurobiology · 2010Review
- A phosphorylation switch regulates the transcriptional activation of cell cycle regulator p21 by histone deacetylase inhibitors.The Journal of biological chemistry · 2010Article
- Regulation of acetylation at the major histocompatibility complex class II proximal promoter by the 19S proteasomal ATPase Sug1.Molecular and cellular biology · 2008Article
- Restriction to Fos family members of Trip6-dependent coactivation and glucocorticoid receptor-dependent trans-repression of activator protein-1.Molecular endocrinology (Baltimore, Md.) · 2008Article
- Extracellular signals regulate rapid coactivator recruitment at AP-1 sites by altered phosphorylation of both CREB binding protein and c-jun.Molecular and cellular biology · 2008Article
- C/EBPbeta induces chromatin opening at a cell-type-specific enhancer.Molecular and cellular biology · 2008Article
- Bypassing the requirements for epigenetic modifications in gene transcription by increasing enhancer strength.Molecular and cellular biology · 2008Article
- In vivo analysis of developmentally and evolutionarily dynamic protein-DNA interactions regulating transcription of the Pgk2 gene during mammalian spermatogenesis.Molecular and cellular biology · 2007Article
- Distinct methylation patterns in histone H3 at Lys-4 and Lys-9 correlate with up- & down-regulation of genes by ethanol in hepatocytes.Life sciences · 2007Article
- Epigenetic activation of the human growth hormone gene cluster during placental cytotrophoblast differentiation.Molecular and cellular biology · 2007Article
- An unmethylated 3' promoter-proximal region is required for efficient transcription initiation.PLoS genetics · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene activation in eukaryotes requires chromatin remodeling, in part via histone modifications. To study the events at the promoter of a mitogen-inducible gene, we examined the induction of expression of the collagenase gene. It has been established that the collagenase gene can be activated by c-Jun and c-Fos and that the transcriptional coactivator p300 is involved in the activation. As expected, we found histone acetyltransferase activity at the collagenase promoter during activation. Interestingly, we also found histone methyltransferase and kinase activity. Strikingly, the first modification observed is methylation of histone H3 lysine 4, which correlates with the binding of the SET9 methyltransferase and the assembly of a complex consisting of c-Jun, c-Fos, TATA binding protein, and RNA polymerase II. The assembly of the preinitiation complex also shows an ordered binding of the acetyltransferase p300, the RSK2 kinase, and the SWI/SNF component Brg-1. Our results suggest that collagenase gene activation involves a dynamic recruitment of different factors and that in addition to acetylation, histone H3 lysine 4 di- and trimethylation and histone H3 serine 10 phosphorylation are important steps in the activation of this gene.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.