ArticleMolecular and cellular biology2003
Far3 and five interacting proteins prevent premature recovery from pheromone arrest in the budding yeast Saccharomyces cerevisiae.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- The fungal STRIPAK complex: Cellular conductor orchestrating growth and pathogenicity.PLoS pathogens · 2025Article
- Yeast gene of unknown functionmicroPublication biology · 2025Article
- STRIPAK, a fundamental signaling hub of eukaryotic development.Microbiology and molecular biology reviews : MMBR · 2024Review
- The Cryptococcus neoformans STRIPAK complex controls genome stability, sexual development, and virulence.PLoS pathogens · 2024Article
- The PP2A-like phosphatase Ppg1 mediates assembly of the Far complex to balance gluconeogenic outputs and enables adaptation to glucose depletion.PLoS genetics · 2024Article
- Evaluation and comparison of colorimetric outputs for yeast-based biosensors in laboratory and point-of-use settings.FEMS microbiology letters · 2024Article
- Mitophagy in yeast: known unknowns and unknown unknowns.The Biochemical journal · 2023Review
- The STRIPAK complex orchestrates cell wall integrity signalling to govern the fungal development and virulence of Fusarium graminearum.Molecular plant pathology · 2023Article
- The GET pathway serves to activate Atg32-mediated mitophagy by ER targeting of the Ppg1-Far complex.Life science alliance · 2023Article
- Post-transcriptional control of fungal cell wall synthesis.Cell surface (Amsterdam, Netherlands) · 2022Article
- The STRIPAK component SipC is involved in morphology and cell-fate determination in the nematode-trapping fungus Duddingtonia flagrans.Genetics · 2022Article
- Characterization ofFrontiers in genetics · 2021Article
- Cell cycle-dependent and independent mating blocks ensure fungal zygote survival and ploidy maintenance.PLoS biology · 2021Article
- Association and dissociation between the mitochondrial Far complex and Atg32 regulate mitophagy.eLife · 2020Article
- The STRIPAK Complex Regulates Response to Chemotherapy Through p21 and p27.Frontiers in cell and developmental biology · 2020Article
- Assembly of a heptameric STRIPAK complex is required for coordination of light-dependent multicellular fungal development with secondary metabolism in Aspergillus nidulans.PLoS genetics · 2019Article
- FAM40A alters the cytoskeleton of podocytes in familial focal and segmental glomerulosclerosis by regulating F-actin and nephrin.Archives of medical science : AMS · 2019Article
- The STRIPAK complex components FAM40A and FAM40B regulate endothelial cell contractility via ROCKs.BMC cell biology · 2018Article
- Genomewide mechanisms of chronological longevity by dietary restriction in budding yeast.Aging cell · 2018Article
- Fsr1, a striatin homologue, forms an endomembrane-associated complex that regulates virulence in the maize pathogen Fusarium verticillioides.Molecular plant pathology · 2018Article
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2 authors.
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Abstract
In budding yeast, diffusible mating pheromones initiate a signaling pathway that culminates in several responses, including cell cycle arrest. Only a handful of genes required for the interface between pheromone response and the cell cycle have been identified, among them FAR1 and FAR3; of these, only FAR1 has been extensively characterized. In an effort to learn about the mechanism by which Far3 acts, we used the two-hybrid method to identify interacting proteins. We identified five previously uncharacterized open reading frames, dubbed FAR7, FAR8, FAR9, FAR10, and FAR11, that cause a far3-like pheromone arrest defect when disrupted. Using two-hybrid and coimmunoprecipitation analysis, we found that all six Far proteins interact with each other. Moreover, velocity sedimentation experiments suggest that Far3 and Far7 to Far11 form a complex. The phenotype of a sextuple far3far7-far11 mutant is no more severe than any single mutant. Thus, FAR3 and FAR7 to FAR11 all participate in the same pathway leading to G1 arrest. These mutants initially arrest in response to pheromone but resume budding after 10 h. Under these conditions, wild-type cells fail to resume budding even after several days whereas far1 mutant cells resume budding within 1 h. We conclude that the FAR3-dependent arrest pathway is functionally distinct from that which employs FAR1.
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