ArticleMolecular and cellular biology2003
Biphasic activation of Aurora-A kinase during the meiosis I- meiosis II transition in Xenopus oocytes.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 49 citations in OpenAlex.
- ANAPHASE-PROMOTING COMPLEX/CYCLOSOME coactivators maintain AURORA 1 kinase homeostasis during meiotic chromosome segregation.The Plant cell · 2025Article
- Ral signaling pathway in health and cancer.Cancer medicine · 2017Review
- The Translation of Cyclin B1 and B2 is Differentially Regulated during Mouse Oocyte Reentry into the Meiotic Cell Cycle.Scientific reports · 2017Article
- The impact of vitrification on murine germinal vesicle oocyte In vitro maturation and aurora kinase A protein expression.Journal of assisted reproduction and genetics · 2014Article
- Perturbing microtubule integrity blocks AMP-activated protein kinase-induced meiotic resumption in cultured mouse oocytes.Zygote (Cambridge, England) · 2014Article
- Xenopus oocyte meiosis lacks spindle assembly checkpoint control.The Journal of cell biology · 2013Article
- Aurora kinase A drives MTOC biogenesis but does not trigger resumption of meiosis in mouse oocytes matured in vivo.Biology of reproduction · 2012Article
- Aurora B regulates spindle bipolarity in meiosis in vertebrate oocytes.Cell cycle (Georgetown, Tex.) · 2012Article
- To polyadenylate or to deadenylate: that is the question.Cell cycle (Georgetown, Tex.) · 2010Review
- Meiosis requires a translational positive loop where CPEB1 ensues its replacement by CPEB4.The EMBO journal · 2010Article
- Kicked by Mos and tuned by MPF-the initiation of the MAPK cascade in Xenopus oocytes.HFSP journal · 2009Article
- Polar body emission requires a RhoA contractile ring and Cdc42-mediated membrane protrusion.Developmental cell · 2008Article
- Aurora kinase A controls meiosis I progression in mouse oocytes.Cell cycle (Georgetown, Tex.) · 2008Article
- Targeted disruption of Aurora A causes abnormal mitotic spindle assembly, chromosome misalignment and embryonic lethality.Oncogene · 2008Article
- Regulation of the Aurora B chromosome passenger protein complex during oocyte maturation in Xenopus laevis.Molecular and cellular biology · 2008Article
- Translational control by cytoplasmic polyadenylation in Xenopus oocytes.Biochimica et biophysica acta · 2008Review
- Ca2+ homeostasis regulates Xenopus oocyte maturation.Biology of reproduction · 2008Article
- Aurora A, mitotic entry, and spindle bipolarity.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- XGef mediates early CPEB phosphorylation during Xenopus oocyte meiotic maturation.Molecular biology of the cell · 2005Article
- Progesterone and insulin stimulation of CPEB-dependent polyadenylation is regulated by Aurora A and glycogen synthase kinase-3.Genes & development · 2004Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Xenopus Aurora-A (also known as Eg2) is a member of the Aurora family of mitotic serine/threonine kinases. In Xenopus oocytes, Aurora-A phosphorylates and activates a cytoplasmic mRNA polyadenylation factor (CPEB) and therefore plays a pivotal role in MOS translation. However, hyperphosphorylation and activation of Aurora-A appear to be dependent on maturation-promoting factor (MPF) activation. To resolve this apparent paradox, we generated a constitutively activated Aurora-A by engineering a myristylation signal at its N terminus. Injection of Myr-Aurora-A mRNA induced germinal vesicle breakdown (GVBD) with the concomitant activation of MOS, mitogen-activated protein kinase, and MPF. Myr-Aurora-A-injected oocytes, however, appeared to arrest in meiosis I with high MPF activity and highly condensed, metaphase-like chromosomes but no organized microtubule spindles. No degradation of CPEB or cyclin B2 was observed following GVBD in Myr-Aurora-A-injected oocytes. In the presence of progesterone, the endogenous Aurora-A became hyperphosphorylated and activated at the time of MPF activation. Following GVBD, Aurora-A was gradually dephosphorylated and inactivated before it was hyperphosphorylated and activated again. This biphasic pattern of Aurora-A activation mirrored that of MPF activation and hence may explain meiosis I arrest by the constitutively activated Myr-Aurora-A.
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