ArticleMolecular and cellular biology2003
Triple decoding of hepatitis C virus RNA by programmed translational frameshifting.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 62 citations in OpenAlex.
- Review
- Unveiling hidden structural patterns in the SARS-CoV-2 genome: Computational insights and comparative analysis.PloS one · 2024Article
- Mouse Liver-Expressed Shiftless Is an Evolutionarily Conserved Antiviral Effector Restricting Human and Murine Hepaciviruses.Microbiology spectrum · 2023Article
- Article
- New tools to analyze overlapping coding regions.BMC bioinformatics · 2016Article
- Truncated yet functional viral protein produced via RNA polymerase slippage implies underestimated coding capacity of RNA viruses.Scientific reports · 2016Article
- Article
- Expression of the novel hepatitis C virus core+1/ARF protein in the context of JFH1-based replicons.Journal of virology · 2015Article
- An alternative -1/+2 open reading frame exists within viral N(pro)(1-19) region of bovine viral diarrhea virus SD-1.Virus research · 2012Article
- The C-terminal alpha-helix domain of apolipoprotein E is required for interaction with nonstructural protein 5A and assembly of hepatitis C virus.Journal of virology · 2010Article
- A long-range RNA-RNA interaction between the 5' and 3' ends of the HCV genome.RNA (New York, N.Y.) · 2009Article
- Seroconversion to hepatitis C virus alternate reading frame protein during acute infection.Hepatology (Baltimore, Md.) · 2009Article
- Ubiquitin-independent degradation of hepatitis C virus F protein.Journal of virology · 2009Article
- Role of the hepatitis C virus core+1 open reading frame and core cis-acting RNA elements in viral RNA translation and replication.Journal of virology · 2008Article
- Expression of alternate reading frame protein (F1) of hepatitis C virus in Escherichia coli and detection of antibodies for F1 in Indian patients.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2008Article
- 3' RNA elements in hepatitis C virus replication: kissing partners and long poly(U).Journal of virology · 2008Article
- Studying hepatitis C virus: making the best of a bad virus.Journal of virology · 2007Review
- Evidence for a functional RNA element in the hepatitis C virus core gene.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- A mechanism of nucleotide misincorporation during transcription due to template-strand misalignment.Molecular cell · 2006Article
- Molecular targets for rapid identification of Brucella spp.BMC microbiology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ribosomes can be programmed to shift from one reading frame to another during translation. Hepatitis C virus (HCV) uses such a mechanism to produce F protein from the -2/+1 reading frame. We now report that the HCV frameshift signal can mediate the synthesis of the core protein of the zero frame, the F protein of the -2/+1 frame, and a 1.5-kDa protein of the -1/+2 frame. This triple decoding function does not require sequences flanking the frameshift signal and is apparently independent of membranes and the synthesis of the HCV polyprotein. Two consensus -1 frameshift sequences in the HCV type 1 frameshift signal facilitate ribosomal frameshifts into both overlapping reading frames. A sequence which is located immediately downstream of the frameshift signal and has the potential to form a double stem-loop structure can significantly enhance translational frameshifting in the presence of the peptidyl-transferase inhibitor puromycin. Based on these results, a model is proposed to explain the triple decoding activities of the HCV ribosomal frameshift signal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.