ArticleJournal of neurology, neurosurgery, and psychiatry2003
Neuropsychological and quality of life outcomes 12 months after unilateral thalamic stimulation for essential tremor.
Article in Journal of neurology, neurosurgery, and psychiatry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Loss of long-term benefit from VIM-DBS in essential tremor: A secondary analysis of repeated measurements.CNS neuroscience & therapeutics · 2022Pooled it
- Enhancing Asleep Deep Brain Stimulation Targeting for Essential Tremor Using Machine Learning: The OPTIVIM Phase 2 Study.Neurosurgery · 2026Trial
- Preventing Parkinson's disease in the context of movement disorders: a narrative review of current evidence and future directions.Neurological research and practice · 2026Review
- Effects of surgical therapies on cognitive function in patients with essential tremor.Journal of the neurological sciences · 2026Article
- Comparative efficacy of PSA and VIM deep brain stimulation in essential tremor: a network and multilevel meta-analysis.Neurosurgical review · 2025Review
- Cognitive outcomes in patients with essential tremor treated with deep brain stimulation: a systematic review.Frontiers in human neuroscience · 2024Review
- Cognitive outcomes following unilateral magnetic resonance-guided focused ultrasound thalamotomy for essential tremor: findings from two cohorts.Brain communications · 2024Article
- Reasons for Hospitalizations and Emergency Department Visits Among Patients with Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024Article
- Evaluation of the effects of DBS in the caudal Zona incerta on brain activity during a working memory task in patients with essential tremor.Neuroimage. Reports · 2023Article
- Analyses of correct responses and errors on measures of verbal fluency among Parkinson's disease and essential tremor patients.The Clinical neuropsychologist · 2023Article
- Neuropsychological assessment protocol in an ongoing randomized controlled trial on posterior subthalamic area vs. ventral intermediate nucleus deep brain stimulation for essential tremor.Frontiers in neurology · 2023Article
- Cognitive subtypes in individuals with essential tremor seeking deep brain stimulation.The Clinical neuropsychologist · 2022Article
- Essential tremor and cognitive impairment: who, how, and why.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Cognitive effects of unilateral thalamotomy for tremor: a meta-analysis.Brain communications · 2022Article
- Neuropsychological outcomes after thalamic deep brain stimulation for essential tremor.Parkinsonism & related disorders · 2021Article
- Thalamic but Not Subthalamic Neuromodulation Simplifies Word Use in Spontaneous Language.Frontiers in human neuroscience · 2021Article
- Cognitive Outcomes for Essential Tremor Patients Selected for Thalamic Deep Brain Stimulation Surgery Through Interdisciplinary Evaluations.Frontiers in human neuroscience · 2020Article
- A Review of Cognitive Outcomes Across Movement Disorder Patients Undergoing Deep Brain Stimulation.Frontiers in neurology · 2019Review
- Subcortical roles in lexical task processing: Inferences from thalamic and subthalamic event-related potentials.Human brain mapping · 2017Article
- Psychiatric and Cognitive Effects of Deep Brain Stimulation for Parkinson's Disease.Current neurology and neuroscience reports · 2016Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the one year cognitive, mood state, and quality of life (QoL) outcomes of unilateral thalamic deep brain stimulation (DBS) for essential tremor (ET).
methods40 patients diagnosed with ET completed comprehensive neuropsychological assessments about one month before and three and 12 months after DBS electrode implantation. Data were subjected to multivariate analyses, and significant results were further analysed using univariate techniques.
resultsAnalyses revealed statistically significant improvements on a cognitive screening measure and in aspects of fine visuomotor and visuoperceptual functions, verbal memory, mood state, and QoL. No group-wise declines in cognition were observed, but more patients showed declines than improvements on language and visual memory tests. Semantic verbal fluency declined significantly in four (10%) of the patients. In these four patients, diminished lexical verbal fluency was present at baseline.
conclusionCognitive, mood, and QoL outcomes after one year of DBS for ET are favourable; there were no overall deleterious effects on cognition, and DBS was accompanied by a significant reduction in anxiety and improvements in quality of life. However, preoperative verbal fluency diminution may predispose to further fluency declines after DBS.
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