Evidence map›Paper›PMID 12588902›Full record

Trial reportThe Journal of physiology2003

alpha1- and alpha2-adrenergic vasoconstriction is blunted in contracting human muscle.

Jaya B Rosenmeier, Frank A Dinenno, Sandy J Fritzlar, Michael J Joyner

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01502787 (Effects of Nebivolol Versus Metoprolol on Blood Flow Responses to Exercise and Angiotensin II in Hypertensive Patients), which is not on this map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
7.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01502787 phase4completednot on this mapstarted 2009, after this paper: background citation

Effects of Nebivolol Versus Metoprolol on Blood Flow Responses to Exercise and Angiotensin II in Hypertensive Patients

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2009 to 2013Enrolled46ConditionsHypertensionArmsMetoprolol succinate, Nebivolol, Forearm blood flow, Microneurography, Rhythmic handgrip exercise
3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 87 citations in OpenAlex.

  1. Trial
  2. Vasoconstrictor responsiveness during hyperbaric hyperoxia in contracting human muscle.Journal of applied physiology (Bethesda, Md. : 1985) · 2013
    Trial
  3. Alpha-adrenergic control of blood flow during exercise: effect of sex and menstrual phase.Journal of applied physiology (Bethesda, Md. : 1985) · 2010
    Trial
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  10. Article
  11. Review
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  18. CORP: Ultrasound assessment of vascular function with the passive leg movement technique.Journal of applied physiology (Bethesda, Md. : 1985) · 2017
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jaya B RosenmeierDepartment of Anesthesiology and General Clinical Research Center, Mayo Clinic and Foundation, 200 First Street SW, Rochester, MN 55905, USA.
Frank A Dinenno
Sandy J Fritzlar
Michael J Joyner
Mayo Clinic · US

Funding

ZESTRIL VS. VERAPAMIL IN THE TREATMENT OF HYPERTENSIONM01RR000585 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 1985 to 2006
$30.4M
PERFUSION OF ACTIVE MUSCLES--METABOLITES AND NERVESR01HL046493 · NHLBI · MAYO CLINIC ROCHESTER · PI JOYNER, MICHAEL J · 1997 to 2011
$3.7M
AGING AND ALPHA-ADRENERGIC CONTROL OF MUSCLE BLOOD FLOWF32AG005912 · NIA · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI DINENNO, FRANK A · 2000 to 2002
$107k
SCALA TYMPANI ELECTRODE ARRAYSN01NS032353 · NINDS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI MERZENICH, MICHAEL M · 1985 to 1987
–
PERFUSION OF ACTIVE MUSCLES: METABOLITES AND NERVESR29HL046493 · NHLBI · MAYO CLINIC COLL OF MEDICINE, ROCHESTER · PI JOYNER, MICHAEL J · 1992 to 1996
–
NCRR NIH HHS M01 RR000585NCRR NIH HHS RR-00585NHLBI NIH HHS HL-46493NHLBI NIH HHS R01 HL046493NIA NIH HHS F32 AG005912NIA NIH HHS F32 AG-05912NINDS NIH HHS N01 NS032353NINDS NIH HHS NS-32353
6 · The paper itself

Abstract

Sympathetic vasoconstriction is blunted in the vascular beds of contracting skeletal muscles. We sought to determine whether this blunted vasoconstriction is specific for post-junctional alpha1- or alpha2-adrenergic receptors. We measured forearm blood flow (Doppler ultrasound) and calculated the vascular conductance (FVC) responses to brachial artery infusions of tyramine (which evokes endogenous noradrenaline release), phenylephrine (an alpha1 agonist) and clonidine (an alpha2 agonist) in 10 healthy men during rhythmic handgrip exercise (10-15 % of maximum) and during a control non-exercise vasodilator condition (intra-arterial adenosine). Steady-state FVC during exercise and adenosine was similar in all trials (range: 243-272 and 234-263 ml min-1 (100 mmHg)-1, respectively; P > 0.5). During exercise the percentage reductions in FVC in response to tyramine (-24 +/- 7 vs. -55 +/- 6 %), phenylephrine (-12 +/- 8 vs. -37 +/- 8 %) and clonidine (-17 +/- 6 vs. -49 +/- 4 %) were significantly less compared with adenosine (all P < 0.05). The magnitude of the blunted vasoconstrictor responses was similar for both receptor subtypes. These findings are in contrast to those from studies in animals demonstrating that alpha2-adrenergic receptor-mediated vasoconstrictor responses are much more sensitive to contraction-induced inhibition than alpha1-mediated responses. We conclude that vasoconstrictor responses mediated via both post-junctional alpha1- and alpha2-adrenergic receptors are blunted in contracting human skeletal muscles.

Indexed as

Adrenergic alpha-AgonistsAdrenergic Uptake InhibitorsAdultClonidineForearmHumansMaleMuscle ContractionMuscle, SkeletalPhenylephrineReceptors, Adrenergic, alpha-1Receptors, Adrenergic, alpha-2TyramineVasoconstrictionAdrenergic alpha-AgonistsAdrenergic Uptake InhibitorsClonidinePhenylephrineReceptors, Adrenergic, alpha-1Receptors, Adrenergic, alpha-2Tyramine

Identifiers

PMID12588902
PMCPMC2342729
OpenAlexW2030118966

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.