ArticleThe Journal of physiology2003
Neurosteroid regulation of oxytocin and vasopressin release from the rat supraoptic nucleus.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 44 citations in OpenAlex.
- Oxytocin affects the connectivity of the precuneus and the amygdala: a randomized, double-blinded, placebo-controlled neuroimaging trial.The international journal of neuropsychopharmacology · 2014Trial
- Reduced osmoresponsiveness in magnocellular neuroendocrine neurones during chronic salt-loading.The Journal of physiology · 2025Article
- Effect of Neurosteroids on Basal and Stress-Induced Oxytocin Secretion in Luteal-Phase and Pregnant Sheep.Animals : an open access journal from MDPI · 2023Article
- Beyond sex and aggression: testosterone rapidly matches behavioural responses to social context and tries to predict the future.Proceedings. Biological sciences · 2022Article
- Oxytocin and vasopressin within the ventral and dorsal lateral septum modulate aggression in female rats.Nature communications · 2021Article
- Acute effect of an infusion ofJournal of traditional and complementary medicine · 2020Article
- Dendritic Release of Neurotransmitters.Comprehensive Physiology · 2016Review
- Physiological regulation of magnocellular neurosecretory cell activity: integration of intrinsic, local and afferent mechanisms.Journal of neuroendocrinology · 2013Review
- Plasticity of calcium signaling cascades in human embryonic stem cell-derived neural precursors.Stem cells and development · 2013Article
- Anabolic androgenic steroid abuse: multiple mechanisms of regulation of GABAergic synapses in neuroendocrine control regions of the rodent forebrain.Journal of neuroendocrinology · 2012Review
- REVIEW: Oxytocin: Crossing the bridge between basic science and pharmacotherapy.CNS neuroscience & therapeutics · 2010Review
- Specific expression of an oxytocin-enhanced cyan fluorescent protein fusion transgene in the rat hypothalamus and posterior pituitary.The Journal of endocrinology · 2010Article
- Ethanol exposure during late gestation and nursing in the rat: effects upon maternal care, ethanol metabolism and infantile milk intake.Pharmacology, biochemistry, and behavior · 2008Article
- Steroid modulation of GABAA receptor-mediated transmission in the hypothalamus: effects on reproductive function.Neuropharmacology · 2007Review
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
In adult rats somato-dendritic release of oxytocin and vasopressin from magnocellular neurones in the supraoptic nucleus of the hypothalamus has important autoregulatory actions on the neuronal electrical activity, and in neonatal rats it plays a role in the development of dendritic arborisation. In the adult, oxytocin effects are modulated by allopregnanolone via an interaction with inhibitory GABAA receptors. This study examined the effects of allopregnanolone, progesterone and 17beta-oestradiol on oxytocin and vasopressin release from intact isolated supraoptic nuclei and from the neurophypophyses in rats of differing ages. In supraoptic nuclei from rats of 3-4 weeks old or less, all three neurosteroids induced oxytocin release from the isolated supraoptic nucleus, but only allopregnanolone induced significant release of vasopressin. Surprisingly, in these very young rats, allopregnanolone-induced oxytocin release was inhibited by GABAA receptor antagonists as well as by an oxytocin receptor antagonist. By contrast, in supraoptic nuclei from adult rats allopregnanolone-induced oxytocin release was much smaller, and was enhanced in the presence of bicuculline. The GABAA receptor agonist muscimol also induced oxytocin release from supraoptic nuclei in young rats, but had no effect in adult rats. Oxytocin cells isolated from young rats showed an increase in [Ca2+]i in response to both allopregnanolone and muscimol. Allopregnanolone had no effect on [Ca2+]i or on the release of oxytocin or vasopressin from neurohypophysial axon terminals in either young or old rats. We conclude that, in very young rats, (i) neurosteroids induce oxytocin release from the supraoptic nucleus by a mechanism that partly depends on the presence of GABA, which in young rats is depolarising to oxytocin cells, and which also partly depends upon endogenous oxytocin, and (ii) the effect of allopregnanolone upon oxytocin release changes with age, as the functional activity of GABAA receptors changes from excitation to inhibition of oxytocin cells.
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