ArticleThe Journal of clinical investigation2003
Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy.
Article in The Journal of clinical investigation, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 91 citations in OpenAlex.
- Hedgehog Inhibitor and Paclitaxel: A Phase I Trial of the Oral Hedgehog inhibitor Taladegib in Combination with Weekly Paclitaxel in Patients with Advanced Solid Tumours.Investigational new drugs · 2026Article
- Recent Advances in Biomolecular Patho-Mechanistic Pathways behind the Development and Progression of Diabetic Neuropathy.Biomedicines · 2024Review
- Sonic Hedgehog Signaling Pathway: A Role in Pain Processing.Neurochemical research · 2023Review
- Selective blood-nerve barrier leakiness with claudin-1 and vessel-associated macrophage loss in diabetic polyneuropathy.Journal of molecular medicine (Berlin, Germany) · 2021Article
- Hedging against Neuropathic Pain: Role of Hedgehog Signaling in Pathological Nerve Healing.International journal of molecular sciences · 2020Review
- Metformin alleviates hyperglycemia-induced endothelial impairment by downregulating autophagy via the Hedgehog pathway.Autophagy · 2019Article
- PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.The Journal of clinical investigation · 2019Article
- Functional and Structural Changes of the Blood-Nerve-Barrier in Diabetic Neuropathy.Frontiers in neuroscience · 2018Review
- Peripheral Glial Cells in the Development of Diabetic Neuropathy.Frontiers in neurology · 2018Review
- Nerves and hydrogen peroxide: how old enemies become new friends.Neural regeneration research · 2017Article
- Schwann cell interactions with axons and microvessels in diabetic neuropathy.Nature reviews. Neurology · 2017Review
- Selective antagonism of muscarinic receptors is neuroprotective in peripheral neuropathy.The Journal of clinical investigation · 2017Article
- Epigenomic Regulation of Schwann Cell Reprogramming in Peripheral Nerve Injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Nerves Control Redox Levels in Mature Tissues Through Schwann Cells and Hedgehog Signaling.Antioxidants & redox signaling · 2016Article
- Trophic and proliferative effects of Shh on motor neurons in embryonic spinal cord culture from wildtype and G93A SOD1 mice.BMC neuroscience · 2013Article
- Voluntary movements as a possible non-reflexive pain assay.Molecular pain · 2013Article
- Cell therapy for diabetic neuropathy using adult stem or progenitor cells.Diabetes & metabolism journal · 2013Article
- Emerging therapy for diabetic neuropathy: cell therapy targeting vessels and nerves.Endocrine, metabolic & immune disorders drug targets · 2012Review
- Sonic hedgehog is cytoprotective against oxidative challenge in a cellular model of amyotrophic lateral sclerosis.Journal of molecular neuroscience : MN · 2012Article
- Estradiol triggers sonic-hedgehog-induced angiogenesis during peripheral nerve regeneration by downregulating hedgehog-interacting protein.Laboratory investigation; a journal of technical methods and pathology · 2012Article
Corrections and comments
- Commented on by
Authors and funding
16 authors at 4 institutions in 2 countries.
Funding
Abstract
Hedgehog proteins modulate development and patterning of the embryonic nervous system. As expression of desert hedgehog and the hedgehog receptor, patched-1, persist in the postnatal and adult peripheral nerves, the hedgehog pathway may have a role in maturation and maintenance of the peripheral nervous system in normal and disease states. We measured desert hedgehog expression in the peripheral nerve of maturing diabetic rats and found that diabetes caused a significant reduction in desert hedgehog mRNA. Treating diabetic rats with a sonic hedgehog-IgG fusion protein fully restored motor- and sensory-nerve conduction velocities and maintained the axonal caliber of large myelinated fibers. Diabetes-induced deficits in retrograde transport of nerve growth factor and sciatic-nerve levels of calcitonin gene-related product and neuropeptide Y were also ameliorated by treatment with the sonic hedgehog-IgG fusion protein, as was thermal hypoalgesia in the paw. These studies implicate disruption of normal hedgehog function in the etiology of diabetes-induced peripheral-nerve dysfunction and indicate that delivery of exogenous hedgehog proteins may have therapeutic potential for the treatment of diabetic neuropathy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.