ArticleAmerican journal of human genetics2003
Use of multivariate linkage analysis for dissection of a complex cognitive trait.
Article in American journal of human genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
39 citing papers in PubMed, 128 citations in OpenAlex.
- Further evidence that the KIAA0319 gene confers susceptibility to developmental dyslexia.Molecular psychiatry · 2006Trial
- A genome scan in multigenerational families with dyslexia: Identification of a novel locus on chromosome 2q that contributes to phonological decoding efficiency.Molecular psychiatry · 2005Trial
- A bivariate genome-wide association study identifies ADAM12 as a novel susceptibility gene for Kashin-Beck disease.Scientific reports · 2016Article
- Genome scan for cognitive trait loci of dyslexia: Rapid naming and rapid switching of letters, numbers, and colors.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2014Article
- Identification of a major locus, TNF1, that controls BCG-triggered tumor necrosis factor production by leukocytes in an area hyperendemic for tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- The genetics of reading disabilities: from phenotypes to candidate genes.Frontiers in psychology · 2012Article
- Genetics of white matter development: a DTI study of 705 twins and their siblings aged 12 to 29.NeuroImage · 2011Article
- In search of the perfect phenotype: an analysis of linkage and association studies of reading and reading-related processes.Behavior genetics · 2011Review
- Dyslexia and DYX1C1: deficits in reading and spelling associated with a missense mutation.Molecular psychiatry · 2010Article
- Article
- Dyslexia and DCDC2: normal variation in reading and spelling is associated with DCDC2 polymorphisms in an Australian population sample.European journal of human genetics : EJHG · 2010Article
- Reconsidering the asymptotic null distribution of likelihood ratio tests for genetic linkage in multivariate variance components models under complete pleiotropy.Biostatistics (Oxford, England) · 2010Article
- Association of reading disabilities with regions marked by acetylated H3 histones in KIAA0319.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- Genetics of developmental dyslexia.European child & adolescent psychiatry · 2010Review
- Multivariate association analysis of the components of metabolic syndrome from the Framingham Heart Study.BMC proceedings · 2009Article
- Comparison of univariate and multivariate linkage analysis of traits related to hypertension.BMC proceedings · 2009Article
- Sex-specific effect of IL9 polymorphisms on lung function and polysensitization.Genes and immunity · 2009Article
- Multivariate association test using haplotype trend regression.Annals of human genetics · 2009Article
- The power of linkage analysis of a disease-related endophenotype using asymmetrically ascertained sib pairs.Computational statistics & data analysis · 2009Article
- Calculating asymptotic significance levels of the constrained likelihood ratio test with application to multivariate genetic linkage analysis.Statistical applications in genetics and molecular biology · 2009Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Replication of linkage results for complex traits has been exceedingly difficult, owing in part to the inability to measure the precise underlying phenotype, small sample sizes, genetic heterogeneity, and statistical methods employed in analysis. Often, in any particular study, multiple correlated traits have been collected, yet these have been analyzed independently or, at most, in bivariate analyses. Theoretical arguments suggest that full multivariate analysis of all available traits should offer more power to detect linkage; however, this has not yet been evaluated on a genomewide scale. Here, we conduct multivariate genomewide analyses of quantitative-trait loci that influence reading- and language-related measures in families affected with developmental dyslexia. The results of these analyses are substantially clearer than those of previous univariate analyses of the same data set, helping to resolve a number of key issues. These outcomes highlight the relevance of multivariate analysis for complex disorders for dissection of linkage results in correlated traits. The approach employed here may aid positional cloning of susceptibility genes in a wide spectrum of complex traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.