ArticleJournal of neurovirology2003
Elevated peripheral benzodiazepine receptor expression in simian immunodeficiency virus encephalitis.
Article in Journal of neurovirology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDS.Journal of neurovirology · 2005Trial
- Imaging of Brain Structural and Functional Effects in People With Human Immunodeficiency Virus.The Journal of infectious diseases · 2023Review
- Osteopontin/secreted phosphoprotein-1 behaves as a molecular brake regulating the neuroinflammatory response to chronic viral infection.Journal of neuroinflammation · 2020Article
- Upregulation of Superoxide Dismutase 2 by Astrocytes in the SIV/Macaque Model of HIV-Associated Neurologic Disease.Journal of neuropathology and experimental neurology · 2020Article
- Regional elevations in microglial activation and cerebral glucose utilization in frontal white matter tracts of rhesus monkeys following prolonged cocaine self-administration.Brain structure & function · 2019Article
- TSPO in diverse CNS pathologies and psychiatric disease: A critical review and a way forward.Pharmacology & therapeutics · 2019Review
- An SIV/macaque model targeted to study HIV-associated neurocognitive disorders.Journal of neurovirology · 2018Review
- Evaluation of prion deposits and microglial activation in scrapie-infected mice using molecular imaging probes.Molecular imaging and biology · 2010Article
- HIV and SIV induce alterations in CNS CaMKII expression and activation: a potential mechanism for cognitive impairment.The American journal of pathology · 2010Article
- Microglia and inflammation in Alzheimer's disease.CNS & neurological disorders drug targets · 2010Review
- Imaging microglial activation during neuroinflammation and Alzheimer's disease.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2009Review
- Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain.Neuropathology and applied neurobiology · 2009Article
- Longitudinal in vivo positron emission tomography imaging of infected and activated brain macrophages in a macaque model of human immunodeficiency virus encephalitis correlates with central and peripheral markers of encephalitis and areas of synaptic degeneration.The American journal of pathology · 2008Article
- Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair.Pharmacology & therapeutics · 2008Review
- The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds to activated and infected brain macrophages in areas of synaptic degeneration: implications for PET imaging of neuroinflammation in lentiviral encephalitis.Neurobiology of disease · 2008Article
- Activated macrophages in HIV encephalitis and a macaque model show increased [3H](R)-PK11195 binding in a PI3-kinase-dependent manner.Neuroscience letters · 2007Article
- The high affinity peripheral benzodiazepine receptor ligand DAA1106 binds specifically to microglia in a rat model of traumatic brain injury: implications for PET imaging.Experimental neurology · 2007Article
- The peripheral benzodiazepine receptor (Translocator protein 18kDa) in microglia: from pathology to imaging.Progress in neurobiology · 2006Review
- Article
- Evaluation of a radiolabelled peripheral benzodiazepine receptor ligand in the central nervous system inflammation of experimental autoimmune encephalomyelitis: a possible probe for imaging multiple sclerosis.European journal of nuclear medicine and molecular imaging · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Measurement of central nervous system (CNS) expression of the peripheral benzodiazepine receptor (PBR), a microglia and macrophage activation marker, by positron emission tomography (PET) would aid clinical management of human immunodeficiency virus (HIV)-infected patients. To evaluate the utility of examining PBR expression in the CNS as a cellular activation marker in HIV CNS disease, PBR levels were measured in frontal cortex of simian immunodeficiency virus (SIV)-infected macaques with encephalitis and uninfected animals via PK11195 ligand autoradiography. [(3)H]-(R)-PK11195 binding to both grey matter (P =.017) and white matter (P =.038) was significantly higher in animals with SIV encephalitis (n = 10) versus control animals (n = 3). When PK11195 binding was compared with other microglial/macrophage activation markers (obtained via quantitative image analysis), a strong, significant association was found for both HAM56 (P =.004) and KP-1 (anti-CD68; P =.006) immunostaining in white matter. In contrast, grey matter PK11195 binding did not correlate with HAM56 (P =.46), KP-1 (P =.06), or glial fibrillary acidic protein (GFAP) immunostaining for astrocytic activation (P =.09). The regional nature of these increases in activation within the brain illustrates the crucial need to focus functional neuroimaging analyses of HIV-infected individuals on subcortical white matter to assess activation of microglia and macrophages.
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Registered trials
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