ArticlePlant physiology2003
In plants, 3-o-methylglucose is phosphorylated by hexokinase but not perceived as a sugar.
Article in Plant physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Abscisic acid strongly promotes anthocyanin accumulation in grape cell suspensions (Vitis vinifera L. cv. 'Gamay Fréaux') independently of glucose concentration.BMC plant biology · 2026Article
- The class VIII myosin ATM1 is required for root apical meristem function.Development (Cambridge, England) · 2023Article
- Grape ASR Regulates Glucose Transport, Metabolism and Signaling.International journal of molecular sciences · 2022Article
- The evolutionarily conserved kinase SnRK1 orchestrates resource mobilization during Arabidopsis seedling establishment.The Plant cell · 2022Article
- Article
- Use of D-glucose-fenpiclonil conjugate as a potent and specific inhibitor of sucrose carriers.Journal of experimental botany · 2017Article
- Expression of Arabidopsis FCS-Like Zinc finger genes is differentially regulated by sugars, cellular energy level, and abiotic stress.Frontiers in plant science · 2015Article
- Sugar regulation of SUGAR TRANSPORTER PROTEIN 1 (STP1) expression in Arabidopsis thaliana.Journal of experimental botany · 2015Article
- Glucose control of root growth direction in Arabidopsis thaliana.Journal of experimental botany · 2014Article
- Functional dissection of sugar signals affecting gene expression in Arabidopsis thaliana.PloS one · 2014Article
- Trehalose 6-phosphate is required for the onset of leaf senescence associated with high carbon availability.Plant physiology · 2012Article
- Regulation of the fruit-specific PEP carboxylase SlPPC2 promoter at early stages of tomato fruit development.PloS one · 2012Article
- MondoA senses non-glucose sugars: regulation of thioredoxin-interacting protein (TXNIP) and the hexose transport curb.The Journal of biological chemistry · 2011Article
- Heterodimers of the Arabidopsis transcription factors bZIP1 and bZIP53 reprogram amino acid metabolism during low energy stress.The Plant cell · 2011Article
- Article
- Sensitive to freezing6 integrates cellular and environmental inputs to the plant circadian clock.Plant physiology · 2008Article
- Ethylene insensitivity results in down-regulation of rubisco expression and photosynthetic capacity in tobacco.Plant physiology · 2007Article
- Sugars proportionately affect artemisinin production.Plant cell reports · 2007Article
- Influence of sugars on blue light-induced chloroplast relocations.Plant signaling & behavior · 2007Article
- Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In plants, sugars are the main respiratory substrates and important signaling molecules in the regulation of carbon metabolism. Sugar signaling studies suggested that sugar sensing involves several key components, among them hexokinase (HXK). Although the sensing mechanism of HXK is unknown, several experiments support the hypothesis that hexose phosphorylation is a determining factor. Glucose (Glc) analogs transported into cells but not phosphorylated are frequently used to test this hypothesis, among them 3-O-methyl-Glc (3-OMG). The aim of the present work was to investigate the effects and fate of 3-OMG in heterotrophic plant cells. Measurements of respiration rates, protein and metabolite contents, and protease activities and amounts showed that 3-OMG is not a respiratory substrate and does not contribute to biosynthesis. Proteolysis and lipolysis are induced in 3-OMG-fed maize (Zea mays L. cv DEA) roots in the same way as in sugar-starved organs. However, contrary to the generally accepted idea, phosphorous and carbon nuclear magnetic resonance experiments and enzymatic assays prove that 3-OMG is phosphorylated to 3-OMG-6-phosphate, which accumulates in the cells. Insofar as plant HXK is involved in sugar sensing, these findings are discussed on the basis of the kinetic properties because the catalytic efficiency of HXK isolated from maize root tips is five orders of magnitude lower for 3-OMG than for Glc and Man.
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