ArticlePlant physiology2003
Powdery mildew-induced Mla mRNAs are alternatively spliced and contain multiple upstream open reading frames.
Article in Plant physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 141 citations in OpenAlex.
- Exploiting plant immune "switches" for resistance engineering.Stress biology · 2026Review
- Alternative splicing in plant stress responses: potential application for crop improvement.Planta · 2025Review
- Discovery of functional NLRs using expression level, high-throughput transformation and large-scale phenotyping.Nature plants · 2025Article
- Diverse epistatic effects in barley-powdery mildew interactions localize to host chromosome hotspots.iScience · 2024Article
- Alternative splicing of a potato disease resistance gene maintains homeostasis between growth and immunity.The Plant cell · 2024Article
- WRR4B contributes to a broad-spectrum disease resistance against powdery mildew in Arabidopsis.Molecular plant pathology · 2024Article
- An interolog-based barley interactome as an integration framework for immune signaling.Genetics · 2022Article
- The Ups and Downs of PlantFrontiers in plant science · 2022Review
- FINDER: an automated software package to annotate eukaryotic genes from RNA-Seq data and associated protein sequences.BMC bioinformatics · 2021Article
- Article
- You Had Me at "MAGIC"!: Four Barley MAGIC Populations Reveal Novel Resistance QTL for Powdery Mildew.Genes · 2020Article
- Role of MPK4 in pathogen-associated molecular pattern-triggered alternative splicing in Arabidopsis.PLoS pathogens · 2020Article
- Genome-wide profiling of alternative splicing genes in hybrid poplar (P.alba×P.glandulosa cv.84K) leaves.PloS one · 2020Article
- Wheat Disease Resistance Genes and Their Diversification Through Integrated Domain Fusions.Frontiers in genetics · 2020Article
- A cell death assay in barley and wheat protoplasts for identification and validation of matching pathogen AVR effector and plant NLR immune receptors.Plant methods · 2019Article
- A malectin-like/leucine-rich repeat receptor protein kinase gene, RLK-V, regulates powdery mildew resistance in wheat.Molecular plant pathology · 2018Article
- Expression of a maize NBS gene ZmNBS42 enhances disease resistance in Arabidopsis.Plant cell reports · 2018Article
- Disease Resistance Mechanisms in Plants.Genes · 2018Review
- Regulation and Evolution of NLR Genes: A Close Interconnection for Plant Immunity.International journal of molecular sciences · 2018Review
- An NB-LRR gene, TYNBS1, is responsible for resistance mediated by the Ty-2 Begomovirus resistance locus of tomato.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In barley (Hordeum vulgare), the Mla13 powdery mildew resistance gene confers Rar1-dependent, AvrMla13-specific resistance to Blumeria graminis f. sp. hordei (Bgh). We have identified cDNA and genomic copies of Mla13 and used this coiled-coil nucleotide-binding site leucine-rich repeat protein-encoding gene as a model for the regulation of host resistance to obligate biotrophic fungi in cereals. We demonstrate quantitatively that a rapid increase in the accumulation of Mla transcripts and transcripts of the Mla-signaling genes, Rar1 and Sgt1, is triggered between 16 and 20 h post inoculation, the same time frame that haustoria of avirulent Bgh make contact with the host cell plasma membrane. An abundance of Mla13 cDNAs revealed five classes of transcript leader regions containing two alternatively spliced introns and up to three upstream open reading frames (uORFs). Alternative splicing of introns in the transcript leader region results in a different number of uORFs and variability in the size of uORF2. These results indicate that regulation of Mla transcript accumulation is not constitutive and that induction is coordinately controlled by recognition-specific factors. The sudden increase in specific transcript levels could account for the rapid defense response phenotype conferred by Mla6 and Mla13.
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