ArticleGenetics2003
Polymorphism and divergence for island-model species.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Isolating selective from non-selective forces using site frequency ratios.PLoS genetics · 2025Article
- The fitness consequences of genetic divergence between polymorphic gene arrangements.Genetics · 2024Article
- The role of migration in mutant dynamics in fragmented populations.Journal of evolutionary biology · 2023Article
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- Effects of Interference Between Selected Loci on the Mutation Load, Inbreeding Depression, and Heterosis.Genetics · 2015Article
- Robust estimates of divergence times and selection with a poisson random field model: a case study of comparative phylogeographic data.Genetics · 2014Article
- Statistical inference of selection and divergence from a time-dependent Poisson random field model.PloS one · 2012Article
- Shifts in the intensity of purifying selection: an analysis of genome-wide polymorphism data from two closely related yeast species.Genome research · 2010Article
- Diffusion approximations for one-locus multi-allele kin selection, mutation and random drift in group-structured populations: a unifying approach to selection models in population genetics.Journal of mathematical biology · 2009Article
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- Population genetics of speciation in two closely related wild tomatoes (Solanum section Lycopersicon).Genetics · 2008Article
- An exact sampling formula for the Wright-Fisher model and a solution to a conjecture about the finite-island model.Genetics · 2007Article
- Weak selection and recent mutational changes influence polymorphic synonymous mutations in humans.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Multiple signatures of positive selection downstream of notch on the X chromosome in Drosophila melanogaster.Genetics · 2005Article
- A composite-likelihood approach for detecting directional selection from DNA sequence data.Genetics · 2005Article
- Article
- Germline bottlenecks, biparental inheritance and selection on mitochondrial variants: a two-level selection model.Genetics · 2005Article
- Article
Corrections and comments
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Authors and funding
1 author.
Funding
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Abstract
Estimates of the scaled selection coefficient, gamma of Sawyer and Hartl, are shown to be remarkably robust to population subdivision. Estimates of mutation parameters and divergence times, in contrast, are very sensitive to subdivision. These results follow from an analysis of natural selection and genetic drift in the island model of subdivision in the limit of a very large number of subpopulations, or demes. In particular, a diffusion process is shown to hold for the average allele frequency among demes in which the level of subdivision sets the timescale of drift and selection and determines the dynamic equilibrium of allele frequencies among demes. This provides a framework for inference about mutation, selection, divergence, and migration when data are available from a number of unlinked nucleotide sites. The effects of subdivision on parameter estimates depend on the distribution of samples among demes. If samples are taken singly from different demes, the only effect of subdivision is in the rescaling of mutation and divergence-time parameters. If multiple samples are taken from one or more demes, high levels of within-deme relatedness lead to low levels of intraspecies polymorphism and increase the number of fixed differences between samples from two species. If subdivision is ignored, mutation parameters are underestimated and the species divergence time is overestimated, sometimes quite drastically. Estimates of the strength of selection are much less strongly affected and always in a conservative direction.
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