ArticleGenetics2003
Sequence variation of alcohol dehydrogenase (Adh) paralogs in cactophilic Drosophila.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Fundamental Patterns of Structural Evolution Revealed by Chromosome-Length Genomes of Cactophilic Drosophila.Genome biology and evolution · 2024Article
- A Bayesian Mutation-Selection Framework for Detecting Site-Specific Adaptive Evolution in Protein-Coding Genes.Molecular biology and evolution · 2021Article
- Genomic analysis of the four ecologically distinct cactus host populations of Drosophila mojavensis.BMC genomics · 2019Article
- Positive selection at sites of chemosensory genes is associated with the recent divergence and local ecological adaptation in cactophilic Drosophila.BMC evolutionary biology · 2018Article
- Behavioral evolution accompanying host shifts in cactophilicEcology and evolution · 2018Article
- Identification of misexpressed genetic elements in hybrids between Drosophila-related species.Scientific reports · 2017Article
- Genome Evolution in Three Species of Cactophilic Drosophila.G3 (Bethesda, Md.) · 2016Article
- No boundaries: genomes, organisms, and ecological interactions responsible for divergence and reproductive isolation.The Journal of heredity · 2014Review
- Divergence in olfactory host plant preference in D. mojavensis in response to cactus host use.PloS one · 2013Article
- Evolutionary toxicogenomics: diversification of the Cyp12d1 and Cyp12d3 genes in Drosophila species.Journal of molecular evolution · 2012Article
- Gene alterations at Drosophila inversion breakpoints provide prima facie evidence for natural selection as an explanation for rapid chromosomal evolution.BMC genomics · 2012Article
- Article
- Molecular evolution and population genetics of two Drosophila mettleri cytochrome P450 genes involved in host plant utilization.Molecular ecology · 2008Article
- Article
- Molecular population genetics of accessory gland protein genes and testis-expressed genes in Drosophila mojavensis and D. arizonae.Genetics · 2005Article
- Ribosomal intergenic spacer (IGS) length variation across the Drosophilinae (Diptera: Drosophilidae).BMC evolutionary biology · 2005Article
- Comparisons of maize pericarp color1 alleles reveal paralogous gene recombination and an organ-specific enhancer region.The Plant cell · 2005Article
- Patterns of intron sequence evolution in Drosophila are dependent upon length and GC content.Genome biology · 2005Article
- Compensatory evolution of a precursor messenger RNA secondary structure in the Drosophila melanogaster Adh gene.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
This study focuses on the population genetics of alcohol dehydrogenase (Adh) in cactophilic Drosophila. Drosophila mojavensis and D. arizonae utilize cactus hosts, and each host contains a characteristic mixture of alcohol compounds. In these Drosophila species there are two functional Adh loci, an adult form (Adh-2) and a larval and ovarian form (Adh-1). Overall, the greater level of variation segregating in D. arizonae than in D. mojavensis suggests a larger population size for D. arizonae. There are markedly different patterns of variation between the paralogs across both species. A 16-bp intron haplotype segregates in both species at Adh-2, apparently the product of an ancient gene conversion event between the paralogs, which suggests that there is selection for the maintenance of the intron structure possibly for the maintenance of pre-mRNA structure. We observe a pattern of variation consistent with adaptive protein evolution in the D. mojavensis lineage at Adh-1, suggesting that the cactus host shift that occurred in the divergence of D. mojavensis from D. arizonae had an effect on the evolution of the larval expressed paralog. Contrary to previous work we estimate a recent time for both the divergence of D. mojavensis and D. arizonae (2.4 +/- 0.7 MY) and the age of the gene duplication (3.95 +/- 0.45 MY).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.