ArticleGenetics2003
Loss of CDC5 function in Saccharomyces cerevisiae leads to defects in Swe1p regulation and Bfa1p/Bub2p-independent cytokinesis.
Article in Genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 40 citations in OpenAlex.
- The Polo kinase Cdc5 is regulated at multiple levels in the adaptation response to telomere dysfunction.Genetics · 2023Article
- Moonlighting at the Poles: Non-Canonical Functions of Centrosomes.Frontiers in cell and developmental biology · 2022Review
- A Potential Antineoplastic Peptide of Human Prostate Cancer Cells Derived from the Lesser Spotted Dogfish (Marine drugs · 2019Article
- The budding yeast Polo-like kinase localizes to distinct populations at centrosomes during mitosis.Molecular biology of the cell · 2017Article
- Mitotic exit and separation of mother and daughter cells.Genetics · 2012Review
- Phosphorylation of Cdc5 regulates its accumulation.Cell division · 2011Article
- Budding yeast Dma1 and Dma2 participate in regulation of Swe1 levels and localization.Molecular biology of the cell · 2011Article
- Meiotic nuclear divisions in budding yeast require PP2A(Cdc55)-mediated antagonism of Net1 phosphorylation by Cdk.The Journal of cell biology · 2011Article
- Phospho-regulation of kinesin-5 during anaphase spindle elongation.Journal of cell science · 2011Article
- Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction.The Journal of biological chemistry · 2010Article
- Cdc7p-Dbf4p regulates mitotic exit by inhibiting Polo kinase.PLoS genetics · 2009Article
- Requirement for the budding yeast polo kinase Cdc5 in proper microtubule growth and dynamics.Eukaryotic cell · 2008Article
- Characterization and evolution of the cell cycle-associated mob domain-containing proteins in eukaryotes.Evolutionary bioinformatics online · 2007Article
- Concerted mechanism of Swe1/Wee1 regulation by multiple kinases in budding yeast.The EMBO journal · 2005Article
- Review
- Novel functional dissection of the localization-specific roles of budding yeast polo kinase Cdc5p.Molecular and cellular biology · 2004Article
- Functional characterization of Dma1 and Dma2, the budding yeast homologues of Schizosaccharomyces pombe Dma1 and human Chfr.Molecular biology of the cell · 2004Article
- M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Coupling morphogenesis to mitotic entry.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
In many organisms, polo kinases appear to play multiple roles during M-phase progression. To provide new insights into the function of budding yeast polo kinase Cdc5p, we generated novel temperature-sensitive cdc5 mutants by mutagenizing the C-terminal domain. Here we show that, at a semipermissive temperature, the cdc5-3 mutant exhibited a synergistic bud elongation and growth defect with loss of HSL1, a component important for normal G(2)/M transition. Loss of SWE1, which phosphorylates and inactivates the budding yeast Cdk1 homolog Cdc28p, suppressed the cdc5-3 hsl1Delta defect, suggesting that Cdc5p functions at a point upstream of Swe1p. In addition, the cdc5-4 and cdc5-7 mutants exhibited chained cell morphologies with shared cytoplasms between the connected cell bodies, indicating a cytokinetic defect. Close examination of these mutants revealed delayed septin assembly at the incipient bud site and loosely organized septin rings at the mother-bud neck. Components in the mitotic exit network (MEN) play important roles in normal cytokinesis. However, loss of BFA1 or BUB2, negative regulators of the MEN, failed to remedy the cytokinetic defect of these mutants, indicating that Cdc5p promotes cytokinesis independently of Bfa1p and Bub2p. Thus, Cdc5p contributes to the activation of the Swe1p-dependent Cdc28p/Clb pathway, normal septin function, and cytokinesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.