ArticleJournal of the American Society for Mass Spectrometry2003
H/D exchange of gas phase bradykinin ions in a linear quadrupole ion trap.
Article in Journal of the American Society for Mass Spectrometry, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Structure Characterization of a Disordered Peptide Using In-Droplet Hydrogen/Deuterium Exchange Mass Spectrometry and Molecular Dynamics.ACS physical chemistry Au · 2025Article
- In-droplet hydrogen-deuterium exchange to examine protein/peptide solution conformer heterogeneity.Rapid communications in mass spectrometry : RCM · 2023Article
- Article
- Characterization of Electrospray Ionization (ESI) Parameters on In-ESI Hydrogen/Deuterium Exchange of Carbohydrate-Metal Ion Adducts.Journal of the American Society for Mass Spectrometry · 2019Article
- Determination of Backbone Amide Hydrogen Exchange Rates of Cytochrome c Using Partially Scrambled Electron Transfer Dissociation Data.Journal of the American Society for Mass Spectrometry · 2018Article
- Time-resolved pulsed hydrogen/deuterium exchange mass spectrometry probes gaseous proteins structural kinetics.Journal of the American Society for Mass Spectrometry · 2015Article
- Atmospheric pressure photo ionization hydrogen/deuterium exchange mass spectrometry--a method to differentiate isomers by mass spectrometry.Journal of the American Society for Mass Spectrometry · 2013Article
- Cis-trans isomerizations of proline residues are key to bradykinin conformations.Journal of the American Chemical Society · 2013Article
- Solution and gas-phase H/D exchange of protein-small-molecule complexes: Cex and its inhibitors.Journal of the American Society for Mass Spectrometry · 2012Article
- On the zwitterionic nature of gas-phase peptides and protein ions.PLoS computational biology · 2010Article
- Gas-phase H/D exchange and collision cross sections of hemoglobin monomers, dimers, and tetramers.Journal of the American Society for Mass Spectrometry · 2009Article
- Conformations of gas-phase ions of ubiquitin, cytochrome c, apomyoglobin, and beta-lactoglobulin produced from two different solution conformations.Journal of the American Society for Mass Spectrometry · 2008Article
- Fragmentation of doubly-protonated peptide ion populations labeled by H/D exchange with CD(3)OD.International journal of mass spectrometry · 2006Article
- Further studies on the origins of asymmetric charge partitioning in protein homodimers.Journal of the American Society for Mass Spectrometry · 2004Article
- Inter-molecular migration during collisional activation monitored by hydrogen/deuterium exchange FT-ICR tandem mass spectrometry.Journal of the American Society for Mass Spectrometry · 2004Article
- The role of acidic residues and of sodium ion adduction on the gas-phase H/D exchange of peptides and peptide dimers.Journal of the American Society for Mass Spectrometry · 2003Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gas phase H/D exchange reaction of bradykinin ions, as well as fragment ions of bradykinin generated through collisions in an orifice skimmer region, have been studied with a linear quadrupole ion trap (LIT) reflectron time-of-flight (rTOF) mass spectrometer system. The reaction in the trap takes only tens of seconds at a pressure of few mTorr of D2O or CD3OD. The exchange rate and hydrogen exchange level are not sensitive to the trapping q value over a broad range, provided q is not close to the stability boundary (q = 0.908). The relative rates and hydrogen exchange levels of protonated and sodiated +1 and +2 ions are similar to those observed previously by others with a Fourier transform ion cyclotron resonance (FTICR) mass spectrometer system. The doubly and triply protonated ions show multimodal isotopic distributions, suggesting the presence of several different conformations. The y fragment ions show greater exchange rates and levels than a or b ions, and when water or ammonia is lost from the fragment ions, no exchange is observed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.