ArticleJournal of virology2003
Reversible oxidative modification as a mechanism for regulating retroviral protease dimerization and activation.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 51 citations in OpenAlex.
- SARS-CoV-2 MNature communications · 2024Article
- Regulation of Retroviral and SARS-CoV-2 Protease Dimerization and Activity through Reversible Oxidation.Antioxidants (Basel, Switzerland) · 2022Review
- Article
- Article
- Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300.bioRxiv : the preprint server for biology · 2021Article
- Dimer Interface Organization is a Main Determinant of Intermonomeric Interactions and Correlates with Evolutionary Relationships of Retroviral and Retroviral-Like Ddi1 and Ddi2 Proteases.International journal of molecular sciences · 2020Article
- Role of Glutathionylation in Infection and Inflammation.Nutrients · 2019Review
- Hepatitis C Virus RNA-Dependent RNA Polymerase Is Regulated by Cysteine S-Glutathionylation.Oxidative medicine and cellular longevity · 2019Article
- Basal Glutathionylation of Na,K-ATPase α-Subunit Depends on Redox Status of Cells during the Enzyme Biosynthesis.Oxidative medicine and cellular longevity · 2016Article
- The cellular redox environment alters antigen presentation.The Journal of biological chemistry · 2014Article
- Understanding HIV-1 protease autoprocessing for novel therapeutic development.Future medicinal chemistry · 2013Article
- Virus-producing cells determine the host protein profiles of HIV-1 virion cores.Retrovirology · 2012Article
- The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer.Free radical biology & medicine · 2011Review
- The initial step in human immunodeficiency virus type 1 GagProPol processing can be regulated by reversible oxidation.PloS one · 2010Article
- Analysis and characterization of dimerization inhibition of a multi-drug-resistant human immunodeficiency virus type 1 protease using a novel size-exclusion chromatographic approach.The Biochemical journal · 2009Article
- Regulation by reversible S-glutathionylation: molecular targets implicated in inflammatory diseases.Molecules and cells · 2008Review
- Thioredoxins, glutaredoxins, and glutathionylation: new crosstalks to explore.Photosynthesis research · 2006Review
- S-glutathionylation: from redox regulation of protein functions to human diseases.Journal of cellular and molecular medicineReview
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Human immunodeficiency virus protease activity can be regulated by reversible oxidation of a sulfur-containing amino acid at the dimer interface. We show here that oxidation of this amino acid in human immunodeficiency virus type 1 protease prevents dimer formation. Moreover, we show that human T-cell leukemia virus type 1 protease can be similarly regulated through reversible glutathionylation of its two conserved cysteine residues. Based on the known three-dimensional structures and multiple sequence alignments of retroviral proteases, it is predicted that the majority of retroviral proteases have sulfur-containing amino acids at the dimer interface. The regulation of protease activity by the modification of a sulfur-containing amino acid at the dimer interface may be a conserved mechanism among the majority of retroviruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.