ArticleGut2003
Enhanced vasodilatation to endothelin antagonism in patients with compensated cirrhosis and the role of nitric oxide.
Article in Gut, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 41 citations in OpenAlex.
- Trial
- The role of endothelin A receptors in peripheral vascular control at rest and during exercise in patients with hypertension.The Journal of physiology · 2020Article
- Endogenous endothelin-1 and femoral artery shear rate: impact of age and implications for atherosclerosis.Journal of hypertension · 2016Article
- Left Ventricular Dilation and Pulmonary Vasodilatation after Surgical Shunt for Treatment of Pre-Sinusoidal Portal Hypertension.PloS one · 2016Article
- Endothelin-A-mediated vasoconstriction during exercise with advancing age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Hepatosplanchnic circulation in cirrhosis and sepsis.World journal of gastroenterology · 2015Review
- Increased endothelin receptor B and G protein coupled kinase-2 in the mesentery of portal hypertensive rats.World journal of gastroenterology · 2013Article
- Taming the "sleeping giant": the role of endothelin-1 in the regulation of skeletal muscle blood flow and arterial blood pressure during exercise.American journal of physiology. Heart and circulatory physiology · 2013Article
- Endothelin and hepatic wound healing.Pharmacological research · 2011Review
- Relationship of 24-hour ambulatory blood pressure and heart rate with markers of hepatic function in cirrhotic patients.BMC gastroenterology · 2010Article
- Possible protection of sinusoidal endothelial cells by endothelin B receptor during hepatic warm ischemia-reperfusion.Surgery today · 2007Article
- Review
- Cardiopulmonary complications in chronic liver disease.World journal of gastroenterology · 2006Review
- Antioxidant effects of insulin-like growth factor-I (IGF-I) in rats with advanced liver cirrhosis.BMC gastroenterology · 2005Article
- Article
- Article
- Article
- Endothelial and microvascular function in liver cirrhosis: an old concept that needs re-evaluation?Annals of gastroenterologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
aimsPatients with advanced cirrhosis have systemic vasodilatation and increased nitric oxide (NO) production despite activated vasopressor systems, including the endothelin system. The aims of this study were to assess the contribution of endogenous endothelin 1 (ET-1) and NO to the maintenance of basal forearm vascular tone in patients with preascitic cirrhosis (n=7) and in age and sex matched healthy controls (n=7).
methodsUsing venous occlusion plethysmography, forearm blood flow (FBF) responses to subsystemic locally active intra-arterial infusion of BQ-123 (a selective endothelin type A receptor (ET(A)) receptor antagonist; 10 nmol/min) were measured before and during application of an "NO clamp": a balanced co-infusion of L-N(G)-monomethyl-arginine (a selective NO synthase inhibitor) and sodium nitroprusside (an exogenous NO donor) to block endogenous NO production and restore NO mediated basal FBF, respectively.
resultsL-NMMA infusion produced a reduction in FBF (p<0.001) which was similar in both groups. Before applying the "NO clamp", BQ-123 caused an increase in FBF in both groups (p<0.001) that was greater in patients with cirrhosis (p<0.01). During the "NO clamp", BQ-123 induced vasodilatation was abolished in controls and attenuated in patients (p<0.001) but remained significantly greater in patients with cirrhosis (p<0.01).
conclusionsThese findings indicate a greater ET(A) mediated contribution of endogenous ET-1 to the maintenance of basal forearm vascular tone in patients with preascitic cirrhosis. In addition, enhanced vasodilatation to ET(A) receptor antagonism in cirrhosis cannot be entirely attributed to NO release but is likely to be related to reversal of direct ET-1 mediated tone.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.