ArticleNucleic acids research2003
Inhibition of human papilloma virus E2 DNA binding protein by covalently linked polyamides.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- The Reservoir of Persistent Human Papillomavirus Infection; Strategies for Elimination Using Anti-Viral Therapies.Viruses · 2022Review
- Modulating DNA by polyamides to regulate transcription factor PU.1-DNA binding interactions.Biochimie · 2019Article
- Article
- Interactions of two large antiviral polyamides with the long control region of HPV16.Biochimie · 2016Article
- New Frontiers in Druggability.Journal of medicinal chemistry · 2015Article
- Tandem trimer pyrrole-imidazole polyamide probes targeting 18 base pairs in human telomere sequences.Chemical science · 2015Article
- Melting thermodynamics of reversible DNA/ligand complexes at interfaces.Journal of the American Chemical Society · 2012Article
- Inhibition of heat shock transcription factor binding by a linear polyamide binding in an unusual 1:1 mode.Chembiochem : a European journal of chemical biology · 2012Article
- HPV episome levels are potently decreased by pyrrole-imidazole polyamides.Antiviral research · 2011Article
- Replication and partitioning of papillomavirus genomes.Advances in virus research · 2008Review
- Recent advances in the search for antiviral agents against human papillomaviruses.Antiviral therapy · 2007Review
- Influence of structural variation on nuclear localization of DNA-binding polyamide-fluorophore conjugates.Nucleic acids research · 2004Article
- Therapeutic modulation of endogenous gene function by agents with designed DNA-sequence specificities.Nucleic acids research · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polyamides are a class of heterocyclic small molecules with the potential of controlling gene expression by binding to the minor groove of DNA in a sequence-specific manner. To evaluate the feasibility of this class of compounds as antiviral therapeutics, molecules were designed to essential sequence elements occurring numerous times in the HPV genome. This sequence element is bound by a virus-encoded transcription and replication factor E2, which binds to a 12 bp recognition site as a homodimeric protein. Here, we take advantage of polyamide:DNA and E2:DNA co-crystal structural information and advances in polyamide synthetic chemistry to design tandem hairpin polyamides that are capable of displacing the major groove-binding E2 homodimer from its DNA binding site. The binding of tandem hairpin polyamides and the E2 DNA binding protein to the DNA site is mutually exclusive even though the two ligands occupy opposite faces of the DNA double helix. We show with circular permutation studies that the tandem hairpin polyamide prevents the intrinsic bending of the E2 DNA site important for binding of the protein. Taken together, these results illustrate the feasibility of inhibiting the binding of homodimeric, major groove-binding transcription factors by altering the local DNA geometry using minor groove-binding tandem hairpin polyamides.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.