ArticleNucleic acids research2003
Protein-protein interaction map for yeast TFIID.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Genetic variability of the activity of bidirectional promoters: a pilot study in bovine muscle.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- Cytoplasmic TAF2-TAF8-TAF10 complex provides evidence for nuclear holo-TFIID assembly from preformed submodules.Nature communications · 2015Article
- Combinatorial depletion analysis to assemble the network architecture of the SAGA and ADA chromatin remodeling complexes.Molecular systems biology · 2011Article
- Yeast two-hybrid map of Arabidopsis TFIID.Plant molecular biology · 2007Article
- Yeast TFIID serves as a coactivator for Rap1p by direct protein-protein interaction.Molecular and cellular biology · 2007Article
- Article
- Metabolic engineering in the -omics era: elucidating and modulating regulatory networks.Microbiology and molecular biology reviews : MMBR · 2005Review
- Mapping and functional characterization of the TAF11 interaction with TFIIA.Molecular and cellular biology · 2005Article
- Charting gene regulatory networks: strategies, challenges and perspectives.The Biochemical journal · 2004Review
- Molecular and genetic characterization of a Taf1p domain essential for yeast TFIID assembly.Molecular and cellular biology · 2004Article
- Mapping key functional sites within yeast TFIID.The EMBO journal · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A major rate-limiting step in transcription initiation by RNA polymerase II is recognition and binding of the TATA element by the transcription factor TFIID. TFIID is composed of TATA binding protein (TBP) and approximately a dozen TBP-associated factors (TAFs). Emerging consensus regarding the role of TAFs is that TFIID assumes a gene specific activity that is regulated by interaction with other factors. In spite of many studies demonstrating the essential nature of TAFs in transcription, very little is known about the subunit contacts within TFIID. To understand fully the functional role of TAFs, it is imperative to define TAF-TAF interactions and their topological arrangement within TFIID. We performed a systematic two-hybrid analysis using the 13 essential TAFs of the Saccharomyces cerevisiae TFIID complex and TBP. Specific interactions were defined for each component, and the biological significance of these interactions is supported by numerous genetic and biochemical studies. By combining the interaction profiles presented here, and the available studies utilizing specific TAFs, we propose a working hypothesis for the arrangement of components in the TFIID complex. Thus, these results serve as a foundation for understanding the overall architecture of yeast TFIID.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.