ArticleNucleic acids research2003
Rap1p and other transcriptional regulators can function in defining distinct domains of gene expression.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Mutational analysis identifies functional Rap1, Su(Hw), and CTCF insulator sites in Arabidopsis thaliana.Plant cell reports · 2020Article
- CisMiner: genome-wide in-silico cis-regulatory module prediction by fuzzy itemset mining.PloS one · 2014Article
- Promoter architectures in the yeast ribosomal expression program.Transcription · 2011Article
- A comprehensive genomic binding map of gene and chromatin regulatory proteins in Saccharomyces.Molecular cell · 2011Article
- Highly transcribed RNA polymerase II genes are impediments to replication fork progression in Saccharomyces cerevisiae.Molecular cell · 2009Article
- A canonical promoter organization of the transcription machinery and its regulators in the Saccharomyces genome.Genome research · 2009Article
- Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatin.Cell · 2005Article
- Interacting models of cooperative gene regulation.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The Yaf9 component of the SWR1 and NuA4 complexes is required for proper gene expression, histone H4 acetylation, and Htz1 replacement near telomeres.Molecular and cellular biology · 2004Article
- Comparison of ABF1 and RAP1 in chromatin opening and transactivator potentiation in the budding yeast Saccharomyces cerevisiae.Molecular and cellular biology · 2004Article
- cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four.Molecular and cellular biology · 2004Article
- Formation of boundaries of transcriptionally silent chromatin by nucleosome-excluding structures.Molecular and cellular biology · 2004Article
- Global nucleosome occupancy in yeast.Genome biology · 2004Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Barrier elements that are able to block the propagation of transcriptional silencing in yeast are functionally similar to chromatin boundary/insulator elements in metazoans that delimit functional chromosomal domains. We show that the upstream activating sequences of many highly expressed ribosome protein genes and glycolytic genes exhibit barrier activity. Analyses of these barriers indicate that binding sites for transcriptional regulators Rap1p, Abf1p, Reb1p, Adr1p and Gcn4p may participate in barrier function. We also present evidence suggesting that Rap1p is directly involved in barrier activity, and its barrier function correlates with local changes in chromatin structure. We further demonstrate that tethering the transcriptional activation domain of Rap1p to DNA is sufficient to recapitulate barrier activity. Moreover, targeting the activation domain of Adr1p or Gcn4p also establishes a barrier to silencing. These results support the notion that transcriptional regulators could also participate in delimiting functional domains in the genome.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.