ArticleNucleic acids research2003
Gene conversion tracts in Saccharomyces cerevisiae can be extremely short and highly directional.
Article in Nucleic acids research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 47 citations in OpenAlex.
- Break-induced replication forms long mutable single-strand DNA during meiosis.Nature communications · 2026Article
- Improved genotype inference reveals cis- and trans-driven variation in the loss-of-heterozygosity rates in yeast.Genetics · 2026Article
- Break-induced replication is activated to repair R-loop-associated double-strand breaks in SETX-deficient cells.Cell reports · 2025Article
- Secure biosystems design inApplied and environmental microbiology · 2025Article
- Loss of heterozygosity results in rapid but variable genome homogenization across yeast genetic backgrounds.eLife · 2021Article
- PIF1 helicase promotes break-induced replication in mammalian cells.The EMBO journal · 2021Article
- Mechanism and Control of Meiotic DNA Double-Strand Break Formation inFrontiers in cell and developmental biology · 2021Review
- Variable Spontaneous Mutation and Loss of Heterozygosity among Heterozygous Genomes in Yeast.Molecular biology and evolution · 2020Article
- Multichromosomal structure and foreign tracts in the Ombrophytum subterraneum (Balanophoraceae) mitochondrial genome.Plant molecular biology · 2020Article
- Frequent Recombination Events inPathogens (Basel, Switzerland) · 2020Article
- Genome Dynamics of HybridG3 (Bethesda, Md.) · 2017Article
- Mitotic Gene Conversion Tracts Associated with Repair of a Defined Double-Strand Break inGenetics · 2017Article
- Review
- Horizontal transfer and gene conversion as an important driving force in shaping the landscape of mitochondrial introns.G3 (Bethesda, Md.) · 2014Article
- Double-strand break repair assays determine pathway choice and structure of gene conversion events in Drosophila melanogaster.G3 (Bethesda, Md.) · 2014Article
- Article
- HGT turbulence: Confounding phylogenetic influence of duplicative horizontal transfer and differential gene conversion.Mobile genetic elements · 2011Article
- Annelid Distal-less/Dlx duplications reveal varied post-duplication fates.BMC evolutionary biology · 2011Article
- Article
- Molecular mechanisms of ultraviolet radiation-induced DNA damage and repair.Journal of nucleic acids · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Gene conversion is a common outcome of double-strand break (DSB) repair in yeast. Prior studies revealed that DSB-induced gene conversion tracts are often short (<53 bp), unidirectional, and biased toward promoter-proximal (5') markers. In those studies, broken ends had short, non-homologous termini. For the present study we created plasmid x chromosome, chromosomal direct repeat and allelic recombination substrates in which donor alleles carried mutant HO sites (HOinc--not cleaved) at the same position as cleavable HO sites in recipient alleles. In these substrates, broken ends are almost completely homologous to donor alleles, differing only at the three HOinc mutations. These mutations serve as markers very close to, or within, the four-base overhang produced by HO nuclease. We identified extremely short tracts (<12 bp) and many tracts were highly directional, extending <2 bp on one side of the DSB. We thought that terminal homology would promote bidirectional tracts, but found instead that unidirectional tracts were more frequent. Interestingly, substrates with terminal homology displayed enhanced 3' conversion, and in several cases conversion bias was reversed toward 3' markers. These results are discussed in relation to factors that may influence tract length and directionality, including heteroduplex DNA formation, transcription, replication and mismatch repair.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.