ArticlePathology oncology research : POR2002
Microsatellite analysis of chromosome 3p region in sporadic renal cell carcinomas.
Article in Pathology oncology research : POR, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Germline mutations in the new E1' cryptic exon of theJournal of medical genetics · 2020Article
- MicroRNA-141 is downregulated in human renal cell carcinoma and regulates cell survival by targeting CDC25B.OncoTargets and therapy · 2013Article
- Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma.Journal of the American Society of Nephrology : JASN · 2005Article
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7 authors.
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Abstract
The etiology and progression of renal carcinomas (RCC) is still poorly understood. RCC have been classified into several pathological entities. The most frequent type, clear cell carcinoma, accounts for about 80% of sporadic RCC and shows several chromosome abnormalities documented both by conventional cytogenetics, loss of eterozygosity (LOH) and replication error (RER) studies. In 10 clear cell type sporadic RCC we evaluated LOH and RER using a set of 10 microsatellite markers covering the chromosome 3p region, which has been suggested for interstitial deletions. Electrophoresis was performed by automated sequencer ABI Prism 377 and data were analyzed with Genescan and Genotyper 2.5 softwares. We revealed allelic loss in 48,7% of informative microsatellites and a single case of RER. We found the highest LOH frequency in 3p25-26 region where maps Von Hippel-Lindau (VHL) oncosuppressor gene. In addition, DNA hypermethylation, an alternative mechanism of VHL gene silencing, was evaluated by methylation-specific PCR. However hypermethylation status was not detected in any of our tumor samples.
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