ArticleProceedings of the National Academy of Sciences of the United States of America2003
Arabidopsis LEAFY COTYLEDON1 represents a functionally specialized subunit of the CCAAT binding transcription factor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.
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112 citing papers in PubMed.
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- Large-scale comparative analysis of the nuclear factor-Y transcription factors across 320 horticultural and other plants.Horticulture research · 2026Article
- Cloning ofInternational journal of molecular sciences · 2025Article
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- The characterization of the LEAFY COTYLEDON 2 activation domains reveals its conserved dual mode of action in flowering plants.The Plant journal : for cell and molecular biology · 2025Article
- Overexpression of PeonyPlants (Basel, Switzerland) · 2025Article
- Transcriptome Analysis Revealed the Regulatory Mechanism of DIMBOA Affecting Early Somatic Embryogenesis inPlants (Basel, Switzerland) · 2025Article
- Article
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- Nuclear factor Y-A3b binds to theHorticulture research · 2024Article
- Peanut LEAFY COTYLEDON1-type genes participate in regulating the embryo development and the accumulation of storage lipids.Plant cell reports · 2024Article
- Genome-Wide Identification of the NF-Y Gene Family and Their Involvement in Bolting and Flowering in Flowering Chinese Cabbage.International journal of molecular sciences · 2023Article
- Comprehensive Analysis of the NF-YB Gene Family and Expression under Abiotic Stress and Hormone Treatment inInternational journal of molecular sciences · 2023Article
- Genome-Wide Identification and Chilling Stress Analysis of the NF-Y Gene Family in Melon.International journal of molecular sciences · 2023Article
- Genetic mapping and functional genomics of soybean seed protein.Molecular breeding : new strategies in plant improvement · 2023Article
- Genome-Wide Characterization ofInternational journal of molecular sciences · 2022Article
- Identification and Characterization of Abiotic Stress-Responsive NF-YB Family Genes inInternational journal of molecular sciences · 2022Article
- Molecular Aspects of Seed Development Controlled by Gibberellins and Abscisic Acids.International journal of molecular sciences · 2022Review
52 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
LEAFY COTYLEDON1 (LEC1) is a central regulator that is required for many aspects of Arabidopsis embryogenesis and sufficient to induce embryo development in vegetative cells when expressed ectopically. We previously showed that LEC1 encodes an HAP3 subunit of the CCAAT binding factor and that the 10 Arabidopsis HAP3 (AHAP3) subunits can be divided into two classes, the LEC1-type and the non-LEC1-type, based on sequence similarity within their B domains. By analyzing the ability of chimeric HAP3 subunits containing different combinations of domains from LEC1 and a non-LEC1-type AHAP3 subunit to suppress genetically the lec1 mutation, we show that the B domain of LEC1 is necessary and sufficient within the context of the protein for its activity in embryogenesis. Moreover, we identify one amino acid residue, Asp-55, specific to the LEC1-type B domain that is required for LEC1 activity in embryogenesis and sufficient to confer partial LEC1 activity to a non-LEC1-type B domain. Based on structural similarities between the HAP3 B domain and histone fold motif, we discuss how the Asp-55 residue may functionally differentiate LEC1 from the non-LEC1-type AHAP3 subunits.
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