ArticleProceedings of the National Academy of Sciences of the United States of America2003
Regulatory gene networks and the properties of the developmental process.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
77 citing papers in PubMed, 227 citations in OpenAlex.
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- PTF-Vāc: An explainable and generative deep co-learning encoder-decoder system for ab initio discovery of plant transcription factor binding sites.Plant communications · 2025Article
- Developmental rewiring of the NGAL/CUC/KLU network associated with pleiotropic roles of NGAL genes.The Plant journal : for cell and molecular biology · 2025Article
- Lhx3/4 initiates a cardiopharyngeal-specific transcriptional program in response to widespread FGF signaling.PLoS biology · 2024Article
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- A single-cell transcriptional timelapse of mouse embryonic development, from gastrula to pup.bioRxiv : the preprint server for biology · 2023Article
- Genetic, morphometric, and molecular analyses of interspecies differences in head shape and hybrid developmental defects in the wasp genus Nasonia.G3 (Bethesda, Md.) · 2021Article
- Single-cell RNA sequencing of theeLife · 2021Article
- A regulatory sub-circuit downstream of Wnt signaling controls developmental transitions in neural crest formation.PLoS genetics · 2021Article
- Network architecture and regulatory logic in neural crest development.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Constructing temporal regulatory cascades in the context of development and cell differentiation.PloS one · 2020Article
- Boolean gene regulatory network model of centromere function in Saccharomyces cerevisiae.Journal of biological physics · 2019Article
- Transcription factor autoregulation is required for acquisition and maintenance of neuronal identity.Development (Cambridge, England) · 2019Article
- Encounters across networks: Windows into principles of genomic regulation.Marine genomics · 2019Article
- Minimum requirements for changing and maintaining endodermis cell identity in the Arabidopsis root.Nature plants · 2018Article
- Threshold response and bistability in gene regulation by small noncoding RNA.The European physical journal. E, Soft matter · 2018Article
- Uncovering Gene Regulatory Networks Controlling Plant Cell Differentiation.Trends in genetics : TIG · 2017Review
- Pathway-related modules involved in the application of sevoflurane or propofol in off-pump coronary artery bypass graft surgery.Experimental and therapeutic medicine · 2017Article
- What determines direction of asymmetry: genes, environment or chance?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Genomic instructions for development are encoded in arrays of regulatory DNA. These specify large networks of interactions among genes producing transcription factors and signaling components. The architecture of such networks both explains and predicts developmental phenomenology. Although network analysis is yet in its early stages, some fundamental commonalities are already emerging. Two such are the use of multigenic feedback loops to ensure the progressivity of developmental regulatory states and the prevalence of repressive regulatory interactions in spatial control processes. Gene regulatory networks make it possible to explain the process of development in causal terms and eventually will enable the redesign of developmental regulatory circuitry to achieve different outcomes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.