ArticleProceedings of the National Academy of Sciences of the United States of America2003
Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed, 130 citations in OpenAlex.
- Review
- Contribution of Dysregulated B-Cells and IgE Antibody Responses to Multiple Sclerosis.Frontiers in immunology · 2022Review
- The Histamine and Multiple Sclerosis Alliance: Pleiotropic Actions and Functional Validation.Current topics in behavioral neurosciences · 2022Article
- Article
- PAF-R on activated T cells: Role in the IL-23/Th17 pathway and relevance to multiple sclerosis.Immunobiology · 2021Article
- Type 2 Inflammatory Responses in Autoimmune Demyelination of the Central Nervous System: Recent Advances.Journal of immunology research · 2019Review
- Serum levels of histamine and diamine oxidase in multiple sclerosis.American journal of clinical and experimental immunology · 2018Article
- Role of Histamine in Modulating the Immune Response and Inflammation.Mediators of inflammation · 2018Review
- Current Understanding of Platelet-Activating Factor Signaling in Central Nervous System Diseases.Molecular neurobiology · 2017Review
- Deficiency of the G protein Gαq ameliorates experimental autoimmune encephalomyelitis with impaired DC-derived IL-6 production and Th17 differentiation.Cellular & molecular immunology · 2017Article
- Treatment with anti-FcεRIα antibody exacerbates EAE and T-cell immunity against myelin.Neurology(R) neuroimmunology & neuroinflammation · 2017Article
- Gαq takes centre stage in multiple sclerosis pathogenesis.Cellular & molecular immunology · 2017Article
- Protection from experimental autoimmune encephalomyelitis by polyclonal IgG requires adjuvant-induced inflammation.Journal of neuroinflammation · 2016Article
- A Liposome-Based Approach to the Integrated Multi-Component Antigen Microarrays.Microarrays (Basel, Switzerland) · 2015Article
- Rheumatoid arthritis vaccine therapies: perspectives and lessons from therapeutic ligand epitope antigen presentation system vaccines for models of rheumatoid arthritis.Expert review of vaccines · 2015Review
- Tryptase is a candidate autoantigen in rheumatoid arthritis.Immunology · 2014Article
- Histamine H₂ receptor signaling × environment interactions determine susceptibility to experimental allergic encephalomyelitis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- Antagonism of histamine H4 receptors exacerbates clinical and pathological signs of experimental autoimmune encephalomyelitis.British journal of pharmacology · 2013Article
- Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity.The Journal of experimental medicine · 2013Article
- Mast cells in the pathogenesis of multiple sclerosis and experimental autoimmune encephalomyelitis.International journal of molecular sciences · 2012Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analysis of mRNA from multiple sclerosis lesions revealed increased amounts of transcripts for several genes encoding molecules traditionally associated with allergic responses, including prostaglandin D synthase, histamine receptor type 1 (H1R), platelet activating factor receptor, Ig Fc epsilon receptor 1 (Fc epsilon RI), and tryptase. We now demonstrate that, in the animal model of multiple sclerosis, experimental autoimmune encephalomyelitis (EAE), mediated by T helper 1 (Th1) T cells, histamine receptor 1 and 2 (H1R and H2R) are present on inflammatory cells in brain lesions. Th1 cells reactive to myelin proteolipid protein expressed more H1R and less H2R than Th2 cells. Pyrilamine, an H1R antagonist, blocked EAE, and the platelet activating factor receptor antagonist CV6209 reduced the severity of EAE. EAE severity was also decreased in mice with disruption of the genes encoding Ig Fc gamma RIII or both Fc gamma RIII and Fc epsilon RI. Prostaglandin D synthase and tryptase transcripts were elevated in EAE brain. Taken together, these data reveal extensive involvement of elements of the immune response associated with allergy in autoimmune demyelination. The pathogenesis of demyelination must now be viewed as encompassing elements of both Th1 responses and "allergic" responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.