ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2003
D5 (not D1) dopamine receptors potentiate burst-firing in neurons of the subthalamic nucleus by modulating an L-type calcium conductance.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 113 citations in OpenAlex.
- Quantitative Systems Pharmacology Development and Application in Neuroscience.Handbook of experimental pharmacology · 2025Review
- Article
- Dopamine internalization via UptakeFrontiers in pharmacology · 2024Article
- Cellular and Synaptic Dysfunctions in Parkinson's Disease: Stepping out of the Striatum.Cells · 2019Review
- D5 dopamine receptors control glutamatergic AMPA transmission between the motor cortex and subthalamic nucleus.Scientific reports · 2018Article
- Antiarrhythmics cure brain arrhythmia: The imperativeness of subthalamic ERG KScience advances · 2017Article
- Dopaminergic and cholinergic modulation of striatal tyrosine hydroxylase interneurons.Neuropharmacology · 2015Article
- Alterations in neuronal activity in basal ganglia-thalamocortical circuits in the parkinsonian state.Frontiers in neuroanatomy · 2015Review
- Localization and function of dopamine receptors in the subthalamic nucleus of normal and parkinsonian monkeys.Journal of neurophysiology · 2014Article
- Involvement of dopamine loss in extrastriatal basal ganglia nuclei in the pathophysiology of Parkinson's disease.Frontiers in aging neuroscience · 2014Review
- Neuronal activity (c-Fos) delineating interactions of the cerebral cortex and basal ganglia.Frontiers in neuroanatomy · 2014Article
- Inhibiting subthalamic D5 receptor constitutive activity alleviates abnormal electrical activity and reverses motor impairment in a rat model of Parkinson's disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Group I mGluRs evoke K-ATP current by intracellular Ca2+ mobilization in rat subthalamus neurons.The Journal of pharmacology and experimental therapeutics · 2013Article
- Basal ganglia activity patterns in parkinsonism and computational modeling of their downstream effects.The European journal of neuroscience · 2012Review
- Article
- Intrinsic dynamics and synaptic inputs control the activity patterns of subthalamic nucleus neurons in health and in Parkinson's disease.Neuroscience · 2011Article
- Pathological basal ganglia activity in movement disorders.Neuroscience · 2011Review
- Modulation of subthalamic T-type Ca(2+) channels remedies locomotor deficits in a rat model of Parkinson disease.The Journal of clinical investigation · 2011Article
- A basis for the pathological oscillations in basal ganglia: the crucial role of dopamine.Neuroreport · 2011Review
- Pharmacology of signaling induced by dopamine D(1)-like receptor activation.Pharmacology & therapeutics · 2010Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dopamine is a crucial factor in basal ganglia functioning. In current models of basal ganglia, dopamine is postulated to act on striatal neurons. However, it may also act on the subthalamic nucleus (STN), a key nucleus in the basal ganglia circuit. The data presented here were obtained in brain slices using whole-cell patch clamp. They reveal that D5 dopamine receptors strengthen electrical activity in the subset of subthalamic neurons endowed with burst-firing capacity, resulting in longer discharges of spontaneous or evoked bursts. To distinguish between D1 and D5 subtypes, the action of agonists in the D1/D5 receptor family was first investigated on rat subthalamic neurons. Single-cell reverse transcription-PCR profiling showed that burst-competent neurons only expressed D5 receptors. Accordingly, receptors localized in postsynaptic membranes within the STN were labeled by a D5-specific antibody. Second, agonists in the D1/D5 family were tested in mouse brain slices. It was found that these agonists were active in D1 receptor knock-out mice in a similar way to wild-type mice or rats. This proved that D5 rather than D1 receptors were involved. Pharmacological tools (dihydropyridines, omega-conotoxins, and calciseptine) were used to identify the target of D5 receptors as an L-type channel. This was reached via G-protein and protein kinase A. The action of dopamine on D5 receptors therefore shapes neuronal activity. It contributes to normal information processing in basal ganglia outside striatum. This finding may be useful in drug therapy for various disorders involving changes in STN activity, such as Parkinson's disease and related disorders.
Indexed as
Identifiers
12574410PMC6741933W2096757255What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.