ArticleJournal of clinical microbiology2003
Candida tropicalis in a neonatal intensive care unit: epidemiologic and molecular analysis of an outbreak of infection with an uncommon neonatal pathogen.
Article in Journal of clinical microbiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Subtractive proteomics-assisted putative drug target and inhibitor identification: a study based on six Candida species.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Outbreak of mucocutaneousAntimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Exponential Clonal Expansion of 5-Fluorocytosine-Resistant Candida tropicalis and New Insights into Underlying Molecular Mechanisms.Emerging infectious diseases · 2025Article
- Outbreaks of Fungal Infections in Hospitals: Epidemiology, Detection, and Management.Journal of fungi (Basel, Switzerland) · 2023Review
- Clinical Features and Outcomes of Persistent Candidemia Caused byMicroorganisms · 2023Article
- Coumarins: antifungal effectiveness and future therapeutic scope.Molecular diversity · 2020Review
- Particularities of the management and the treatment in a rare sepsis with Candida tropicalis of a Collodion baby: Case report.Medicine · 2017Article
- Emergence of non-albicans Candida species in neonatal candidemia.North American journal of medical sciences · 2013Article
- Epidemiology and microbiology of nosocomial pediatric candidemia at a northern Indian tertiary care hospital.Mycopathologia · 2011Article
- Candidemia and candiduria in critically ill patients admitted to intensive care units in France: incidence, molecular diversity, management and outcome.Intensive care medicine · 2008Article
- [Recommendation for the prevention of nosocomial infections in neonatal intensive care patients with a birth weight less than 1,500 g. Report by the Committee of Hospital Hygiene and Infection Prevention of the Robert Koch Institute].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2007Article
- Identification of medically important yeast species by sequence analysis of the internal transcribed spacer regions.Journal of clinical microbiology · 2006Article
- Use of quantitative real-time PCR to study the kinetics of extracellular DNA released from Candida albicans, with implications for diagnosis of invasive Candidiasis.Journal of clinical microbiology · 2006Article
- Epidemiology and molecular typing of Candida isolates from burn patients.Mycopathologia · 2004Article
- Neonatal candidiasis: analysis of epidemiology, drug susceptibility, and molecular typing of causative isolates.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2004Article
- Clinical microbiology of bacterial and fungal sepsis in very-low-birth-weight infants.Clinical microbiology reviews · 2004Review
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Authors and funding
10 authors.
Funding
Abstract
From June to July 1998, two episodes of Candida tropicalis fungemia occurred in the Aristotle University neonatal intensive care unit (ICU). To investigate this uncommon event, a prospective study of fungal colonization and infection was conducted. From December 1998 to December 1999, surveillance cultures of the oral cavities and perinea of the 593 of the 781 neonates admitted to the neonatal ICU who were expected to stay for >7 days were performed. Potential environmental reservoirs and possible risk factors for acquisition of C. tropicalis were searched for. Molecular epidemiologic studies by two methods of restriction fragment length polymorphism analysis and two methods of random amplified polymorphic DNA analysis were performed. Seventy-two neonates were colonized by yeasts (12.1%), of which 30 were colonized by Candida albicans, 17 were colonized by C. tropicalis, and 5 were colonized by Candida parapsilosis. From December 1998 to December 1999, 10 cases of fungemia occurred; 6 were due to C. parapsilosis, 2 were due to C. tropicalis, 1 was due to Candida glabrata, and 1 was due to Trichosporon asahii (12.8/1,000 admissions). Fungemia occurred more frequently in colonized than in noncolonized neonates (P < 0.0001). Genetic analysis of 11 colonization isolates and the two late blood isolates of C. tropicalis demonstrated two genotypes. One blood isolate and nine colonization isolates belonged to a single type. The fungemia/colonization ratio of C. parapsilosis (3/5) was greater than that of C. tropicalis (2/17, P = 0.05), other non-C. albicans Candida spp. (1/11, P = 0.02), or C. albicans (0/27, P = 0.05). Extensive environmental cultures revealed no common source of C. tropicalis or C. parapsilosis. There was neither prophylactic use of azoles nor other risk factors found for acquisition of C. tropicalis except for total parenteral nutrition. A substantial risk of colonization by non-C. albicans Candida spp. in the neonatal ICU may lead to a preponderance of C. tropicalis as a significant cause of neonatal fungemia.
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