ArticleThe EMBO journal2003
Light-regulated translation mediates gated induction of the Arabidopsis clock protein LHY.
Article in The EMBO journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
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Who cites it
79 citing papers in PubMed.
- Abundant clock proteins point to missing molecular regulation in the plant circadian clock.Molecular systems biology · 2025Article
- Nature's Master of Ceremony: TheNpj biological timing and sleep · 2025Article
- Decoding the plant clock: a review of mathematical models for the circadian regulatory network.Plant molecular biology · 2024Review
- Evolution and Dynamic Transcriptome of Key Genes of Photoperiodic Flowering Pathway in Water Spinach (International journal of molecular sciences · 2024Article
- Prioritizing candidate eQTL causal genes in Arabidopsis using RANDOM FORESTS.G3 (Bethesda, Md.) · 2022Article
- Circadian rhythms in the plant host influence rhythmicity of rhizosphere microbiota.BMC biology · 2022Article
- Rhythms of Transcription in Field-Grown Sugarcane Are Highly Organ Specific.Scientific reports · 2020Article
- Article
- Chemical Perturbation of Chloroplast-Related Processes Affects Circadian Rhythms of Gene Expression inFrontiers in physiology · 2020Article
- Circadian Rhythms in Plants.Cold Spring Harbor perspectives in biology · 2019Review
- Phenotypic and Genomic Local Adaptation across Latitude and Altitude in Populus trichocarpa.Genome biology and evolution · 2019Article
- The Plant Circadian Oscillator.Biology · 2019Review
- Novel pipeline identifies new upstream ORFs and non-AUG initiating main ORFs with conserved amino acid sequences in the 5' leader of mRNAs inRNA (New York, N.Y.) · 2019Article
- Beyond Transcription: Fine-Tuning of Circadian Timekeeping by Post-Transcriptional Regulation.Genes · 2018Review
- Daily humidity oscillation regulates the circadian clock to influence plant physiology.Nature communications · 2018Article
- Multiple feedback loops of the Arabidopsis circadian clock provide rhythmic robustness across environmental conditions.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- How does temperature affect splicing events? Isoform switching of splicing factors regulates splicing of LATE ELONGATED HYPOCOTYL (LHY).Plant, cell & environment · 2018Article
- Identification, characterization and gene expression analyses of important flowering genes related to photoperiodic pathway in bamboo.BMC genomics · 2018Article
- Recent Discoveries on the Role of TOR (Target of Rapamycin) Signaling in Translation in Plants.Plant physiology · 2018Review
- What makes ribosomes tick?RNA biology · 2018Review
19 more citing papers are in PubMed but not listed here.
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4 authors.
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Abstract
The transcription factor LHY and the related protein CCA1 perform overlapping functions in a regulatory feedback loop that is closely associated with the circadian oscillator of Arabidopsis: Overexpression of LHY abolished function of the circadian clock in constant light, but rhythmic expression of several circadian clock-regulated transcripts was observed under light- dark cycles. These oscillations correlated with high amplitude changes in LHY protein levels, caused by light-induced translation of the LHY transcript. Increases in LHY protein levels were also observed in light-grown wild-type plants, when light signals coincided with the circadian-regulated peak of LHY transcription at dawn. Unexpectedly, translational induction coincided with acute downregulation of LHY transcript levels. We suggest that the simultaneous translational induction and transcriptional repression of LHY expression play a role to narrow the peak of LHY protein synthesis at dawn and increase the robustness and accuracy of circadian oscillations. Strong phase shifting responses to light signals were observed in plants lacking function of LHY, CCA1 or both, suggesting that light-regulated expression of these proteins does not mediate entrainment of the clock to light-dark cycles.
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