ReviewAnnual review of biophysics and biomolecular structure2003
The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors.
Review in Annual review of biophysics and biomolecular structure, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 133 citations in OpenAlex.
- Structural determinants of ligand response specificity in the mast cell activating GPCR, MRGPRX2.The Journal of biological chemistry · 2026Article
- The rhodopsin-retinochrome system for retinal re-isomerization predates the origin of cephalopod eyes.BMC ecology and evolution · 2021Article
- Photic generation of 11-The Journal of biological chemistry · 2019Article
- Characterization of G-protein coupled receptors from the blackback land crab Gecarcinus lateralis Y organ transcriptome over the molt cycle.BMC genomics · 2019Article
- Species differences in cannabinoid receptor 2 and receptor responses to cocaine self-administration in mice and rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Chemistry and biology of the initial steps in vision: the Friedenwald lecture.Investigative ophthalmology & visual science · 2014Article
- The receptor concept in 3D: from hypothesis and metaphor to GPCR-ligand structures.Neurochemical research · 2014Review
- Chemistry of the retinoid (visual) cycle.Chemical reviews · 2014Review
- From atomic structures to neuronal functions of g protein-coupled receptors.Annual review of neuroscience · 2013Review
- A hybrid structural approach to analyze ligand binding by the serotonin type 4 receptor (5-HT4).Molecular & cellular proteomics : MCP · 2013Article
- The significance of G protein-coupled receptor crystallography for drug discovery.Pharmacological reviews · 2011Review
- Molecular mechanisms of disease for mutations at Gly-90 in rhodopsin.The Journal of biological chemistry · 2011Article
- New insights into the binding mode of melanin concentrating hormone receptor-1 antagonists: homology modeling and explicit membrane molecular dynamics simulation study.Journal of chemical information and modeling · 2011Article
- Focus on vision: 3 decades of remarkable contributions to biology and medicine.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2011Article
- Structural fragment clustering reveals novel structural and functional motifs in alpha-helical transmembrane proteins.BMC bioinformatics · 2010Article
- Topology of class A G protein-coupled receptors: insights gained from crystal structures of rhodopsins, adrenergic and adenosine receptors.Molecular pharmacology · 2009Review
- Comparative docking study of anibamine as the first natural product CCR5 antagonist in CCR5 homology models.Journal of chemical information and modeling · 2009Article
- Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors.Current pharmaceutical design · 2009Review
- Vertebrate membrane proteins: structure, function, and insights from biophysical approaches.Pharmacological reviews · 2008Review
- Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction.Cellular signalling · 2008Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
G protein-coupled receptors (GPCRs) are integral membrane proteins that respond to environmental signals and initiate signal transduction pathways activating cellular processes. Rhodopsin is a GPCR found in rod cells in retina where it functions as a photopigment. Its molecular structure is known from cryo-electron microscopic and X-ray crystallographic studies, and this has reshaped many structure/function questions important in vision science. In addition, this first GPCR structure has provided a structural template for studies of other GPCRs, including many known drug targets. After presenting an overview of the major structural elements of rhodopsin, recent literature covering the use of the rhodopsin structure in analyzing other GPCRs will be summarized. Use of the rhodopsin structural model to understand the structure and function of other GPCRs provides strong evidence validating the structural model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.