ArticleThe Biochemical journal2003
High-mobility group A1 proteins are overexpressed in human leukaemias.
Article in The Biochemical journal, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Flavopiridol induces BCL-2 expression and represses oncogenic transcription factors in leukemic blasts from adults with refractory acute myeloid leukemia.Leukemia & lymphoma · 2011Trial
- Critical role of the high mobility group A proteins in hematological malignancies.Hematological oncology · 2022Review
- Down Syndrome Fetal Fibroblasts Display Alterations of Endosomal Trafficking Possibly due to SYNJ1 Overexpression.Frontiers in genetics · 2022Article
- HMGA Proteins in Hematological Malignancies.Cancers · 2020Review
- Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice.Cell death & disease · 2019Article
- miR-26a suppresses osteosarcoma migration and invasion by directly targeting HMGA1.Oncology letters · 2018Article
- High mobility group A1 protein modulates autophagy in cancer cells.Cell death and differentiation · 2017Article
- HMGA1-pseudogenes and cancer.Oncotarget · 2016Review
- The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development.Current molecular medicine · 2016Review
- Genetic ablation of homeodomain-interacting protein kinase 2 selectively induces apoptosis of cerebellar Purkinje cells during adulthood and generates an ataxic-like phenotype.Cell death & disease · 2015Article
- Deregulation of HMGA1 expression induces chromosome instability through regulation of spindle assembly checkpoint genes.Oncotarget · 2015Article
- RNA-Mediated Regulation of HMGA1 Function.Biomolecules · 2015Review
- Article
- The high mobility group A1 molecular switch: turning on cancer - can we turn it off?Expert opinion on therapeutic targets · 2014Review
- Hmga1/Hmga2 double knock-out mice display a "superpygmy" phenotype.Biology open · 2014Article
- The Wnt/β-catenin/T-cell factor 4 pathway up-regulates high-mobility group A1 expression in colon cancer.Cell biochemistry and function · 2013Article
- High mobility group A1 protein acts as a new target of Notch1 signaling and regulates cell proliferation in T leukemia cells.Molecular and cellular biochemistry · 2013Article
- Hmga1 is differentially expressed and mediates silencing of the CD4/CD8 loci in T cell lineages and leukemic cells.Cancer science · 2012Article
- Identification of nuclear protein targets for six leukemogenic tyrosine kinases governed by post-translational regulation.PloS one · 2012Article
- High mobility group A: a novel biomarker and therapeutic target in pancreatic adenocarcinoma.The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland · 2009Review
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High-mobility group A (HMGA) proteins are non-histone nuclear proteins that bind DNA and several transcription factors. They are involved in the regulation of chromatin structure and function. HMGA protein expression is low in normal adult tissues, but abundant during embryonic development and in several human tumours. Rearrangements of the HMGA genes have been frequently detected in human benign tumours of mesenchymal origin, e.g. lipomas, lung hamartomas and uterine leiomiomas. HMGA proteins have been implicated in the control of cell growth and differentiation of the pre-adipocytic cell line 3T3-L1. In an attempt to better understand the role of HMGA1 proteins in haematological neoplasias and in the differentiation of haematopietic cells, we have investigated their expression in human leukaemias and in leukaemic cell lines induced to terminal differentiation. Here we report HMGA1 overexpression in most fresh human leukaemias of different origin and in several leukaemic cell lines. Moreover, differentiation of three cell lines towards the megakaryocytic phenotype was associated with HMGA1 protein induction, whereas induction of erythroid and monocytic differentiation generally resulted in reduced HMGA1 expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.