ArticleJournal of gastroenterology2002
Intestinal subepithelial myofibroblasts in inflammatory bowel diseases.
Article in Journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Nanoencapsulated Syzygium aromaticum oil alleviates acetic acid-induced ulcerative colitis in rats by influencing critical redox, NF-κB/iNOS, and Keap1/Nrf2/HO-1 signaling pathways.Inflammopharmacology · 2025Article
- Inhibition of intestinal inflammation and fibrosis by Scutellaria Baicalensis georgi and Boswellia serrata in human epithelial cells and fibroblasts.Immunity, inflammation and disease · 2024Article
- Colonic mucosa barrier defects in collagenous and ischemic colitis.Histology and histopathology · 2024Article
- Molecular Basis of Intestinal Fibrosis in Inflammatory Bowel Disease.Inflammatory intestinal diseases · 2023Review
- Murine Precision-cut Intestinal Slices as a Potential Screening Tool for Antifibrotic Drugs.Inflammatory bowel diseases · 2020Article
- Patient-derived small intestinal myofibroblasts direct perfused, physiologically responsive capillary development in a microfluidic Gut-on-a-Chip Model.Scientific reports · 2020Article
- DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells.Cell reports · 2019Article
- Role of Apple Phytochemicals, Phloretin and Phloridzin, in Modulating Processes Related to Intestinal Inflammation.Nutrients · 2019Article
- Cellular Interactions in the Intestinal Stem Cell Niche.Archivum immunologiae et therapiae experimentalis · 2019Review
- Mechanism and therapeutic effects of Saccharomyces boulardii on experimental colitis in mice.Molecular medicine reports · 2018Article
- Epidermal growth factor is a critical regulator of the cytokine IL-33 in intestinal epithelial cells.British journal of pharmacology · 2016Article
- IL-33 activates tumor stroma to promote intestinal polyposis.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Epimorphin(-/-) mice are protected, in part, from acute colitis via decreased interleukin 6 signaling.Translational research : the journal of laboratory and clinical medicine · 2014Article
- Stem cells as potential therapeutic targets for inflammatory bowel disease.Frontiers in bioscience (Scholar edition) · 2010Review
- Isolation and culture of fibroblasts from endoscopic duodenal biopsies of celiac patients.Journal of translational medicine · 2009Article
- Inhibitory effects of short-chain fatty acids on matrix metalloproteinase secretion from human colonic subepithelial myofibroblasts.Digestive diseases and sciences · 2009Article
- Endometrial-peritoneal interactions during endometriotic lesion establishment.The American journal of pathology · 2008Article
- Inflammatory bowel disease: Moving toward a stem cell-based therapy.World journal of gastroenterology · 2008Review
- Interaction between interleukin-17-producing CD4+ T cells and colonic subepithelial myofibroblasts: what are they doing in mucosal inflammation?Journal of gastroenterology · 2007Review
- Novel pathophysiological concepts of inflammatory bowel disease.Journal of gastroenterology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colonic subepithelial myofibroblasts (SEMFs) may play a role in the regulation of a number of epithelial cell functions and in the mucosal repair process. In this study, we evaluated the changes in alpha-smooth muscle actin (SMA)- and vimentin-positive SEMFs in the inflamed mucosa of inflammatory bowel disease (IBD) patients. Tissue samples were surgically obtained from patients with active ulcerative colitis (UC) (n = 5) and active Crohn's disease (CD) (n = 5). Normal intestinal tissues were also obtained (n = 5). The SMA and vimentin expression was evaluated by standard immunohistochemical procedures. In normal intestinal mucosa, SMA- and vimentin-positive SEMFs were located immediately subjacent to the basement membrane, juxtaposed against the bottom site of the epithelial cells. In the inflamed mucosa of active UC patients, there were relatively more SMA-positive cells compared with normal mucosa. In particular, the increase in SMA-positive cells was greatest at the marginal area of deep ulcers of UC patients. In active CD mucosa, SMA-positive cells were increased in all samples, and a marked increase was observed in two samples. The number of SMA-positive SEMFs was relatively higher in CD mucosa than in UC mucosa. An [3H]thymidine incorporation study demonstrated that platelet-derived growth factor (PDGF)-BB, basic fibroblast growth factor (bFGF), and insulin-like growth factor (IGF)-I significantly increased the uptake of [3H]thymidine into isolated SEMFs. In particular, PDGF had a strong stimulatory effect. We concluded that colonic SEMFs may play an important role in the repair process of IBD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.