ArticleJournal of gastroenterology2002
Possible involvement of neutrophil elastase in impaired mucosal repair in patients with ulcerative colitis.
Article in Journal of gastroenterology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Neutrophil Elastase and Elafin in Inflammatory Bowel Diseases: Urinary Biomarkers Reflecting Intestinal Barrier Dysfunction and Proteolytic Activity.Journal of clinical medicine · 2025Article
- Neutrophils: From Inflammatory Bowel Disease to Colitis-Associated Colorectal Cancer.Journal of inflammation research · 2025Review
- Neutrophils in Inflammatory Diseases: Unraveling the Impact of Their Derived Molecules and Heterogeneity.Cells · 2023Review
- Hyaluronic Acid in Synovial Fluid Prevents Neutrophil Activation in Spondyloarthritis.International journal of molecular sciences · 2023Article
- Elafin and its precursor trappin-2: What is their therapeutic potential for intestinal diseases?British journal of pharmacology · 2023Review
- PR1P, a VEGF-stabilizing peptide, reduces injury and inflammation in acute lung injury and ulcerative colitis animal models.Frontiers in immunology · 2023Article
- Polyphenols and Maillard Reaction Products in DriedMolecules (Basel, Switzerland) · 2022Article
- Neutrophil Extracellular Trap Density Increases With Increasing Histopathological Severity of Crohn's Disease.Inflammatory bowel diseases · 2022Article
- Polyphenol-Enriched Extracts ofMolecules (Basel, Switzerland) · 2022Article
- Dichotomous roles of neutrophils in modulating pathogenic and repair processes of inflammatory bowel diseases.Precision clinical medicine · 2021Review
- Estrogen-related receptor alpha (ERRα) is a key regulator of intestinal homeostasis and protects against colitis.Scientific reports · 2021Article
- High circulating elafin levels are associated with Crohn's disease-associated intestinal strictures.PloS one · 2020Article
- Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease.Scientific reports · 2019Article
- Understanding the Multifaceted Role of Neutrophils in Cancer and Autoimmune Diseases.Frontiers in immunology · 2018Review
- The Dual Role of Neutrophils in Inflammatory Bowel Diseases.Journal of clinical medicine · 2016Review
- Alpha-1-antitrypsin therapy ameliorates acute colitis and chronic murine ileitis.Inflammatory bowel diseases · 2013Article
- Neutrophil elastase in colitis: more than a marker of disease activity?Journal of gastroenterology · 2006Article
- Inhibition of neutrophil elastase prevents the development of murine dextran sulfate sodium-induced colitis.Journal of gastroenterology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLittle information is available on the relative contribution of peptide growth factors and leukocyte-derived proteinases to the repair processes in inflammatory bowel disease (IBD). We investigated their possible roles in epithelial cell restitution and proliferation in patients with IBD.
methodsThe expression of hepatocyte growth factor (HGF), keratinocyte growth factor (KGF), transforming growth factor-beta (TGF-beta), and neutrophil elastase (NE) was examined in colonic mucosal tissues. The effects of organ culture supernatants of mucosal tissues on epithelial cell restitution and proliferation were analyzed in vitro using an intestinal cell line, IEC-6 cells.
resultsMost organ cultures detected the presence of measurable levels of HGF, with a relative paucity of KGF and TGF-beta activity. Greater levels of HGF were obtained in the mucosa involved with IBD, especially in patients with ulcerative colitis (UC). The mucosa involved with UC also showed higher amounts of NE. The supernatants from the mucosa involved with UC possessed a prominent stimulatory effect on the restitution of IEC-6 cells. By contrast, significant suppression beyond baseline levels was observed for the proliferation of IEC-6 cells when they were incubated with recombinant HGF plus the supernatants from the mucosa involved with UC. This suppression was diminished considerably by preincubation of the supernatants with the anti-NE antibody.
conclusionsHGF produced in the intestinal mucosa may be an important stimulator acting on epithelial cell restitution in patients with IBD. However, NE released in situ may impair mucosal repair through inhibiting epithelial cell proliferation in patients with UC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.