Evidence map›Paper›PMID 12571649›Full record

Trial reportEuropean journal of clinical nutrition2003

Lack of benefit of dietary advice to men with angina: results of a controlled trial.

M L Burr, P A L Ashfield-Watt, F D J Dunstan, A M Fehily, P Breay, T Ashton, P C Zotos, N A A Haboubi, P C Elwood

Abstract readClinical TrialRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in European journal of clinical nutrition, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 20 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 20 syntheses or guidelines pooled it.

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  16. Omega-3 polyunsaturated fatty acids (PUFA) for type 2 diabetes mellitus.The Cochrane database of systematic reviews · 2008
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  17. Fish-oil supplementation in patients with implantable cardioverter defibrillators: a meta-analysis.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2008
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  20. Omega 3 fatty acids for prevention and treatment of cardiovascular disease.The Cochrane database of systematic reviews · 2004
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45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

M L BurrUniversity of Wales College of Medicine, Cardiff, UK. michael.burr@bro-taf-ha.wales.nhs.uk
P A L Ashfield-Watt
F D J Dunstan
A M Fehily
P Breay
T Ashton
P C Zotos
N A A Haboubi
P C Elwood

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo see whether mortality among men with angina can be reduced by dietary advice.

designA randomized controlled factorial trial.

settingMale patients of general practitioners in south Wales. SUBJECTS: A total of 3114 men under 70 y of age with angina.

interventionsSubjects were randomly allocated to four groups: (1) advised to eat two portions of oily fish each week, or to take three fish oil capsules daily; (2) advised to eat more fruit, vegetables and oats; (3) given both the above types of advice; and (4) given no specific dietary advice. Mortality was ascertained after 3-9 y.

resultsCompliance was better with the fish advice than with the fruit advice. All-cause mortality was not reduced by either form of advice, and no other effects were attributable to fruit advice. Risk of cardiac death was higher among subjects advised to take oily fish than among those not so advised; the adjusted hazard ratio was 1.26 (95% confidence interval 1.00, 1.58; P=0.047), and even greater for sudden cardiac death (1.54; 95% CI 1.06, 2.23; P=0.025). The excess risk was largely located among the subgroup given fish oil capsules. There was no evidence that it was due to interactions with medication.

conclusionsAdvice to eat more fruit was poorly complied with and had no detectable effect on mortality. Men advised to eat oily fish, and particularly those supplied with fish oil capsules, had a higher risk of cardiac death. This result is unexplained; it may arise from risk compensation or some other effect on patients' or doctors' behaviour.

Indexed as

AvenaDietFruitVegetablesAngina Pectorisbeta CaroteneEicosapentaenoic AcidFatty Acids, UnsaturatedFish OilsHumansMaleMiddle AgedNutritional SciencesSurvival AnalysisTime FactorsWalesbeta CaroteneEicosapentaenoic AcidFatty Acids, UnsaturatedFish Oils

Identifiers

PMID12571649

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.