ArticleGene therapy2003
Enabling topical immunization via microporation: a novel method for pain-free and needle-free delivery of adenovirus-based vaccines.
Article in Gene therapy, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- In vivo, in situ imaging of microneedle insertion into the skin of human volunteers using optical coherence tomography.Pharmaceutical research · 2011Trial
- Evolution of Transdermal Drug Delivery Devices and Novel Microneedle Technologies: A Historical Perspective and Review.JID innovations : skin science from molecules to population health · 2023Review
- Recent advances in epicutaneous immunotherapy and potential applications in food allergy.Frontiers in allergy · 2023Review
- Copper sulfide nanostructures: synthesis and biological applications.RSC advances · 2022Review
- Transdermal drug delivery systems for fighting common viral infectious diseases.Drug delivery and translational research · 2021Review
- Article
- Therapeutic efficacy of nanoparticles and routes of administration.Biomaterials research · 2019Review
- Topical and Transdermal Drug Delivery: From Simple Potions to Smart Technologies.Current drug delivery · 2019Review
- Nucleic acid delivery into skin for the treatment of skin disease: Proofs-of-concept, potential impact, and remaining challenges.Journal of controlled release : official journal of the Controlled Release Society · 2015Review
- Microneedle-mediated transcutaneous immunization with plasmid DNA coated on cationic PLGA nanoparticles.Journal of controlled release : official journal of the Controlled Release Society · 2012Article
- Hollow copper sulfide nanoparticle-mediated transdermal drug delivery.Small (Weinheim an der Bergstrasse, Germany) · 2012Article
- A physically transient form of silicon electronics.Science (New York, N.Y.) · 2012Article
- Delivery systems for intradermal vaccination.Current topics in microbiology and immunology · 2012Review
- Microsecond thermal ablation of skin for transdermal drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2011Article
- Enabling skin vaccination using new delivery technologies.Drug delivery and translational research · 2011Article
- Formulation and coating of microneedles with inactivated influenza virus to improve vaccine stability and immunogenicity.Journal of controlled release : official journal of the Controlled Release Society · 2010Article
- Selective removal of stratum corneum by microdermabrasion to increase skin permeability.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2009Article
- The hairless mouse in skin research.Journal of dermatological science · 2009Review
- Micro-scale devices for transdermal drug delivery.International journal of pharmaceutics · 2008Review
- Transdermal drug delivery.Nature biotechnology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The skin represents an excellent site for vaccine inoculation due to its natural role as a first line of contact with foreign pathogens and the high local frequency of antigen presenting cells. To facilitate skin-directed immunization, a new technique has been developed (termed microporation) whereby a vaporization process is used to remove tiny areas of the stratum corneum creating microscopic pores that allow access to the underlying viable epidermis. Reporter gene expression was 100-fold increased following application of an adenovirus vector to microporated skin when compared to intact skin. Furthermore, 10-100-fold greater cellular and humoral immune responses were observed following topical administration of an adenovirus vaccine to microporated skin versus intact skin. Hairless mice responded to the microporated adenovirus vaccine equivalently to mice with normal hair follicle distribution demonstrating the activity of the microporated vaccine was not related to follicle count. In a tumor challenge model using a surrogate antigen, microporation increased vaccine efficacy by approximately 100-fold compared to intact skin. Finally, microporation enabled delivery of an adenovirus vaccine carrying a relevant melanoma antigen resulting in the development of auto-immune vitiligo and tumor protection. Thus, the microporation technology has proven to be a reliable and easy method to enable skin-directed vaccination.
Indexed as
Identifiers
12571633What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.