ArticleThe Plant cell2003
The eto1, eto2, and eto3 mutations and cytokinin treatment increase ethylene biosynthesis in Arabidopsis by increasing the stability of ACS protein.
Article in The Plant cell, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 157 papers.
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Who cites it
157 citing papers in PubMed, 372 citations in OpenAlex.
- Ethylene signalling enhances mitochondrial stress tolerance independently of the transcription factor ANAC017 in Arabidopsis.Journal of experimental botany · 2026Article
- Genome-wide identification and characterization of 1-amino-cyclopropane-1- carboxylate synthase (ACS) gene family in Carica papaya and expression insights in response to hormone stress.BMC plant biology · 2026Article
- Cytokinin derivatives as tools to enhance plant stress resilience.Frontiers in plant science · 2026Review
- The role of ACS genes in sex differentiation of Siraitia grosvenorii revealed by comparative transcriptomic analysis.BMC plant biology · 2025Article
- Article
- To grow or not to grow: the enigma of plant root growth dynamism.Plant molecular biology · 2025Review
- Ethylene biosynthesis in legumes: gene identification and expression during early symbiotic stages.Journal of experimental botany · 2025Article
- Cytokinin negatively regulates tomato fruit ripening by influencing the ethylene pathway.Plant cell reports · 2025Article
- Identification of two postharvest ripening regulatory models in kiwifruit: based on plant hormones, physiology, and transcriptome analysis.BMC plant biology · 2024Article
- Cytokinins regulate spatially specific ethylene production to control root growth in Arabidopsis.Plant communications · 2024Article
- The Potential Diagnostic Utility of SMAD4 and ACCS in the Context of Inflammation in Type 2 Diabetes Mellitus Patients.Biomedicines · 2024Article
- Comprehensive analysis of MAPK gene family in upland cotton (Gossypium hirsutum) and functional characterization of GhMPK31 in regulating defense response to insect infestation.Plant cell reports · 2024Article
- Profiling of 1-aminocyclopropane-1-carboxylic acid and selected phytohormones in Arabidopsis using liquid chromatography-tandem mass spectrometry.Plant methods · 2024Article
- The Ethylene Biosynthetic Enzymes, 1-Aminocyclopropane-1-Carboxylate (ACC) Synthase (ACS) and ACC Oxidase (ACO): The Less Explored Players in Abiotic Stress Tolerance.Biomolecules · 2024Review
- GhXB38D represses cotton fibre elongation through ubiquitination of ethylene biosynthesis enzymes GhACS4 and GhACO1.Plant biotechnology journal · 2023Article
- Article
- A role for ethylene signaling and biosynthesis in regulating and accelerating COThe New phytologist · 2023Article
- Kinetin induces microtubular breakdown, cell cycle arrest and programmed cell death in tobacco BY-2 cells.Protoplasma · 2023Article
- Ethylene Inhibition Reduces De Novo Shoot Organogenesis and Subsequent Plant Development from Leaf Explants ofPlants (Basel, Switzerland) · 2023Article
- Whole-Genome Comparison Reveals Structural Variations behind Heading Leaf Trait inInternational journal of molecular sciences · 2023Article
97 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Arabidopsis ethylene-overproducing mutants eto1, eto2, and eto3 have been suggested to affect the post-transcriptional regulation of 1-aminocyclopropane-1-carboxylic acid synthase (ACS). Here, we present the positional cloning of the gene corresponding to the dominant eto3 mutation and show that the eto3 phenotype is the result of a missense mutation within the C-terminal domain of ACS9, which encodes one isoform of the Arabidopsis ACS gene family. This mutation is analogous to the dominant eto2 mutation that affects the C-terminal domain of the highly similar ACS5. Analysis of purified recombinant ACS5 and epitope-tagged ACS5 in transgenic Arabidopsis revealed that eto2 does not increase the specific activity of the enzyme either in vitro or in vivo; rather, it increases the half-life of the protein. In a similar manner, cytokinin treatment increased the stability of ACS5 by a mechanism that is at least partially independent of the eto2 mutation. The eto1 mutation was found to act by increasing the function of ACS5 by stabilizing this protein. These results suggest that an important mechanism by which ethylene biosynthesis is controlled is the regulation of the stability of ACS, mediated at least in part through the C-terminal domain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.