ArticleJournal of medical genetics2003
Association of the CD14 gene -159C polymorphism with progression of IgA nephropathy.
Article in Journal of medical genetics, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Identification of pyroptosis-related hub genes and immune cell infiltration in IgA nephropathy via bioinformatics analysis.Renal failure · 2026Article
- Selection signatures associated with adaptation in South African Drakensberger, Nguni, and Tuli beef breeds.Tropical animal health and production · 2024Article
- IgA nephropathy: gut microbiome regulates the production of hypoglycosilated IgA1 via the TLR4 signaling pathway.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Article
- Blood and urine biomarkers of disease progression in IgA nephropathy.Biomarker research · 2024Review
- Is There a Role for Gut Microbiome Dysbiosis in IgA Nephropathy?Microorganisms · 2022Review
- The mucosal immune system and IgA nephropathy.Seminars in immunopathology · 2021Review
- Sexual Dimorphic Role of CD14 (Cluster of Differentiation 14) in Salt-Sensitive Hypertension and Renal Injury.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Ovine CD14- an Immune Response Gene Has a Role Against Gastrointestinal NematodeFrontiers in immunology · 2021Article
- Kawasaki disease: pathophysiology and insights from mouse models.Nature reviews. Rheumatology · 2020Review
- Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation.Immunity · 2019Article
- The gut-kidney axis in IgA nephropathy: role of microbiota and diet on genetic predisposition.Pediatric nephrology (Berlin, Germany) · 2018Article
- The Interplay Between Host Genetic Variation, Viral Replication, and Microbial Translocation in Untreated HIV-Infected Individuals.The Journal of infectious diseases · 2015Article
- Can tonsillectomy modify the innate and adaptive immunity pathways involved in IgA nephropathy?Journal of nephrology · 2015Article
- Genetics and immunopathogenesis of IgA nephropathy.Clinical reviews in allergy & immunology · 2011Review
- Association between toll-like receptor 10 (TLR10) gene polymorphisms and childhood IgA nephropathy.European journal of pediatrics · 2011Article
- Lack of effect of the CD14 promoter gene C-159T polymorphism on nutritional status parameters in hemodialysis patients.Medical science monitor : international medical journal of experimental and clinical research · 2011Article
- Molecular Characterization and SNP Detection of CD14 Gene of Crossbred Cattle.Molecular biology international · 2011Article
- Toll-like receptor 4 expression is increased in circulating mononuclear cells of patients with immunoglobulin A nephropathy.Clinical and experimental immunology · 2010Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The risk factors associated with the progression of IgA nephropathy (IgAN), the most common form of glomerulonephritis, are unclear. It has been suggested that CD14 signalling in response to various microbes affects the natural history of chronic inflammatory conditions. It has been hypothesised that variants in the promoter region of the CD14 gene might alter the expression of CD14, and this in turn could influence the progressive nature of IgAN. PCR-RFLP was used to determine the polymorphism at the -159 site (T to C). The distribution of the CD14/-159 polymorphism was no different in patients with IgAN (n=216) compared to 171 healthy controls. After follow up for 86 months, it was found that an excess of the C genotype occurred in patients with progressive disease (p=0.03) and the risk of disease progression increased as the number of C alleles increased (p for trend = 0.002). The hazard ratio for progression in the patients with the CC genotype was 3.2 (p=0.025) compared with the patients possessing the TT genotype. After LPS stimulation, sCD14 was released more abundantly from the PBMCs of the TT subjects than from that of the CC subjects (p=0.006), even though mCD14 expression level was no different. In addition, the TT subjects released less IL-6 than the CC subjects after stimulation (p=0.0003). These results suggest that the CD14/-159 polymorphism is an important marker for the progression of IgAN and may modulate the level of the inflammatory responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.