ArticleGenome research2003
Sequence analysis of a functional Drosophila centromere.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
84 citing papers in PubMed, 168 citations in OpenAlex.
- Genomic and epigenomic maps of mouse centromeres and pericentromeres.Nature communications · 2025Article
- ThemicroPublication biology · 2025Article
- Centromere structure and function: lessons from Drosophila.Genetics · 2023Article
- Identification and characterization of centromeric sequences inGenome research · 2021Article
- Sequence, Chromatin and Evolution of Satellite DNA.International journal of molecular sciences · 2021Review
- Centromeres Transcription and Transcripts for Better and for Worse.Progress in molecular and subcellular biology · 2021Article
- Review
- Targeted De Novo Centromere Formation in Drosophila Reveals Plasticity and Maintenance Potential of CENP-A Chromatin.Developmental cell · 2020Article
- Article
- Transcriptional silencing of centromere repeats by heterochromatin safeguards chromosome integrity.Current genetics · 2019Review
- Islands of retroelements are major components of Drosophila centromeres.PLoS biology · 2019Article
- Article
- Article
- Centromere transcription allows CENP-A to transit from chromatin association to stable incorporation.The Journal of cell biology · 2018Article
- Article
- Simple and Complex Centromeric Satellites inGenetics · 2018Article
- Dissecting the Satellite DNA Landscape in Three CactophilicG3 (Bethesda, Md.) · 2017Article
- Segmental Duplication of Chromosome 11 and its Implications for Cell Division and Genome-wide Expression in Rice.Scientific reports · 2017Article
- Centromeres Drive a Hard Bargain.Trends in genetics : TIG · 2017Review
- Article
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Centromeres are the site for kinetochore formation and spindle attachment and are embedded in heterochromatin in most eukaryotes. The repeat-rich nature of heterochromatin has hindered obtaining a detailed understanding of the composition and organization of heterochromatic and centromeric DNA sequences. Here, we report the results of extensive sequence analysis of a fully functional centromere present in the Drosophila Dp1187 minichromosome. Approximately 8.4% (31 kb) of the highly repeated satellite DNA (AATAT and TTCTC) was sequenced, representing the largest data set of Drosophila satellite DNA sequence to date. Sequence analysis revealed that the orientation of the arrays is uniform and that individual repeats within the arrays mostly differ by rare, single-base polymorphisms. The entire complex DNA component of this centromere (69.7 kb) was sequenced and assembled. The 39-kb "complex island" Maupiti contains long stretches of a complex A+T rich repeat interspersed with transposon fragments, and most of these elements are organized as direct repeats. Surprisingly, five single, intact transposons are directly inserted at different locations in the AATAT satellite arrays. We find no evidence for centromere-specific sequences within this centromere, providing further evidence for sequence-independent, epigenetic determination of centromere identity and function in higher eukaryotes. Our results also demonstrate that the sequence composition and organization of large regions of centric heterochromatin can be determined, despite the presence of repeated DNA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.