ArticleGenome research2003
Genomic sequence and transcriptional profile of the boundary between pericentromeric satellites and genes on human chromosome arm 10p.
Article in Genome research, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 65 citations in OpenAlex.
- Development and validation of a novel glioblastoma prognostic model: identifying STOX1 and ZNF248 as ferroptosis-related biomarkers.Cancer cell international · 2025Article
- Reconstruction of Segmental Duplication Rates and Associated Genomic Features by Network Analysis.Genome biology and evolution · 2025Article
- Integration of bioinformatics analysis reveals ZNF248 as a potential prognostic and immunotherapeutic biomarker for LIHC: machine learning and experimental evidence.American journal of cancer research · 2024Article
- Genome-wide allele and haplotype-sharing patterns suggested one unique Hmong-Mein-related lineage and biological adaptation history in Southwest China.Human genomics · 2023Article
- Expression pattern of ZNF33B in bovine ovaries and the effect of its polymorphism on superovulation traits.Archives animal breeding · 2022Article
- Modelling segmental duplications in the human genome.BMC genomics · 2021Article
- Gene-based analysis identified the gene ZNF248 is associated with late-onset asthma in African Americans.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2016Article
- Human embryonic stem cells derived from embryos at different stages of development share similar transcription profiles.PloS one · 2011Article
- Article
- Evolutionary dynamics of segmental duplications from human Y-chromosomal euchromatin/heterochromatin transition regions.Genome research · 2008Article
- Islands of euchromatin-like sequence and expressed polymorphic sequences within the short arm of human chromosome 21.Genome research · 2007Article
- Mapping of the juxtacentromeric heterochromatin-euchromatin frontier of human chromosome 21.Genome research · 2006Article
- Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes.Genome research · 2006Article
- Dynamic evolution at pericentromeres.Genome research · 2006Article
- Retrotransposon accumulation and satellite amplification mediated by segmental duplication facilitate centromere expansion in rice.Genome research · 2006Article
- The evolutionary dynamics of alpha-satellite.Genome research · 2006Article
- Punctuated duplication seeding events during the evolution of human chromosome 2p11.Genome research · 2005Article
- Article
- Complex genomic rearrangements lead to novel primate gene function.Genome research · 2005Article
- A genome-wide survey of segmental duplications that mediate common human genetic variation of chromosomal architecture.Human genomics · 2004Article
Corrections and comments
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Authors and funding
16 authors at 2 institutions in 4 countries.
Funding
Abstract
Contiguous finished sequence from highly duplicated pericentromeric regions of human chromosomes is needed if we are to understand the role of pericentromeric instability in disease, and in gene and karyotype evolution. Here, we have constructed a BAC contig spanning the transition from pericentromeric satellites to genes on the short arm of human chromosome 10, and used this to generate 1.4 Mb of finished genomic sequence. Combining RT-PCR, in silico gene prediction, and paralogy analysis, we can identify two domains within the sequence. The proximal 600 kb consists of satellite-rich pericentromerically duplicated DNA which is transcript poor, containing only three unspliced transcripts. In contrast, the distal 850 kb contains four known genes (ZNF248, ZNF25, ZNF33A, and ZNF37A) and up to 32 additional transcripts of unknown function. This distal region also contains seven out of the eight intrachromosomal duplications within the sequence, including the p arm copy of the approximately 250-kb duplication which gave rise to ZNF33A and ZNF33B. By sequencing orthologs of the duplicated ZNF33 genes we have established that ZNF33A has diverged significantly at residues critical for DNA binding but ZNF33B has not, indicating that ZNF33B has remained constrained by selection for ancestral gene function. These results provide further evidence of gene formation within intrachromosomal duplications, but indicate that recent interchromosomal duplications at this centromere have involved transcriptionally inert, satellite rich DNA, which is likely to be heterochromatic. This suggests that any novel gene structures formed by these interchromosomal events would require relocation to a more open chromatin environment to be expressed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.