ReviewNature reviews. Immunology2003
The complementary roles of deletion and regulation in transplantation tolerance.
Review in Nature reviews. Immunology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A common gene signature across multiple studies relate biomarkers and functional regulation in tolerance to renal allograft.Kidney international · 2015Pooled it
- Trial
- Trial
- Impact of SIRPα genotype combinations in recipients and donors on alloimmune response in liver transplantation.PNAS nexus · 2025Article
- Review
- Nanoparticle-Based Interventions for Liver Transplantation.International journal of molecular sciences · 2023Review
- Novel T cell/organoid culture system allowsFrontiers in immunology · 2023Article
- The role of IL-6 in hyperlipidemia-induced accelerated rejection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- Mettl14-mediated m6A modification enhances the function of Foxp3Frontiers in immunology · 2022Article
- Balancing B cell responses to the allograft: implications for vaccination.Frontiers in immunology · 2022Review
- An Unbiased Machine Learning Exploration Reveals Gene Sets Predictive of Allograft Tolerance After Kidney Transplantation.Frontiers in immunology · 2021Article
- B Cells Control Mucosal-Associated Invariant T Cell Responses toFrontiers in immunology · 2021Article
- Bioinformatics analyses on the immune status of renal transplant patients, a systemic research of renal transplantation.BMC medical genomics · 2020Article
- Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms.Circulation · 2019Article
- Regulatory T cells in the treatment of disease.Nature reviews. Drug discovery · 2018Review
- CD4+CD25Xenotransplantation · 2018Article
- Transplant trials with Tregs: perils and promises.The Journal of clinical investigation · 2017Review
- IL-2-MediatedFrontiers in immunology · 2017Article
- A Novel Model on DST-Induced Transplantation Tolerance by the Transfer of Self-Specific Donor tTregs to a Haplotype-Matched Organ Recipient.Frontiers in immunology · 2017Article
- Involvement of indirectly allostimulated CD4+CD43highCD45RO+ T cell proliferation in the development of chronic allograft nephropathy.Experimental biology and medicine (Maywood, N.J.) · 2016Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neonatal tolerance of alloantigens was described in mice nearly half a century ago, but unfortunately, the translation of these early findings into the clinical arena proved to be much more challenging than was first anticipated. However, the past decade has seen considerable progress in our understanding of the mechanisms that contribute to transplantation tolerance in experimental models. This review outlines our current understanding of the mechanisms of allograft tolerance, emphasizing the complementary roles of deletion and regulation of alloreactive T cells.
Indexed as
Identifiers
12563298What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.