ArticleThe Journal of physiology2003
Background and tandem-pore potassium channels in magnocellular neurosecretory cells of the rat supraoptic nucleus.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Navigating Central Oxytocin Transport: Known Realms and Uncharted Territories.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025Review
- The Inhibition of TREK-1 KInternational journal of molecular sciences · 2024Article
- Osmoregulation and the Hypothalamic Supraoptic Nucleus: From Genes to Functions.Frontiers in physiology · 2022Review
- Contribution of K2P Potassium Channels to Cardiac Physiology and Pathophysiology.International journal of molecular sciences · 2021Review
- Advances in the neurophysiology of magnocellular neuroendocrine cells.Journal of neuroendocrinology · 2020Review
- Tandem pore TWIK-related potassium channels and neuroprotection.Neural regeneration research · 2019Review
- Ion Channels in the Paraventricular Hypothalamic Nucleus (PVN); Emerging Diversity and Functional Roles.Frontiers in physiology · 2018Review
- Expression and localisation of two-pore domain (K2P) background leak potassium ion channels in the mouse retina.Scientific reports · 2017Article
- Formation of Functional Heterodimers by TREK-1 and TREK-2 Two-pore Domain Potassium Channel Subunits.The Journal of biological chemistry · 2016Article
- Much more than a leak: structure and function of K₂p-channels.Pflugers Archiv : European journal of physiology · 2015Review
- The TREK2 Channel Is Involved in the Proliferation of 253J Cell, a Human Bladder Carcinoma Cell.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2013Article
- Properties of BK-type Ca(+) (+)-dependent K(+) channel currents in medial prefrontal cortex pyramidal neurons in rats of different ages.Frontiers in cellular neuroscience · 2013Article
- Expression of K2P channels in sensory and motor neurons of the autonomic nervous system.Journal of molecular neuroscience : MN · 2012Article
- Diverse roles of G-protein coupled receptors in the regulation of neurohypophyseal hormone secretion.Journal of neuroendocrinology · 2012Review
- Colitis decreases mechanosensitive K2P channel expression and function in mouse colon sensory neurons.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Activation of TREK currents by the neuroprotective agent riluzole in mouse sympathetic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Cerebrovascular responses in mice deficient in the potassium channel, TREK-1.American journal of physiology. Regulatory, integrative and comparative physiology · 2010Article
- Characterization of TWIK-2, a two-pore domain K+ channel, cloned from the rat middle cerebral artery.Experimental biology and medicine (Maywood, N.J.) · 2009Article
- The response of the tandem pore potassium channel TASK-3 (K(2P)9.1) to voltage: gating at the cytoplasmic mouth.The Journal of physiology · 2009Article
- Heteromeric TASK-1/TASK-3 is the major oxygen-sensitive background K+ channel in rat carotid body glomus cells.The Journal of physiology · 2009Article
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Authors and funding
4 authors.
Funding
Abstract
Magnocellular neurosecretory cells (MNCs) were isolated from the supraoptic nucleus of rat hypothalamus, and properties of K(+) channels that may regulate the resting membrane potential and the excitability of MNCs were studied. MNCs showed large transient outward currents, typical of vasopressin- and oxytocin-releasing neurons. K(+) channels in MNCs were identified by recording K(+) channels that were open at rest in cell-attached and inside-out patches in symmetrical 150 mM KCl. Eight different K(+) channels were identified and could be distinguished unambiguously by their single-channel kinetics and voltage-dependent rectification. Two K(+) channels could be considered functional correlates of TASK-1 and TASK-3, as judged by their single-channel kinetics and high sensitivity to pH(o). Three K(+) channels showed properties similar to TREK-type tandem-pore K(+) channels (TREK-1, TREK-2 and a novel TREK), as judged by their activation by membrane stretch, intracellular acidosis and arachidonic acid. One K(+) channel was activated by application of pressure, arachidonic acid and alkaline pH(i), and showed single-channel kinetics indistinguishable from those of TRAAK. One K(+) channel showed strong inward rectification and single-channel conductance similar to those of a classical inward rectifier, IRK3. Finally, a K(+) channel whose cloned counterpart has not yet been identified was highly sensitive to extracellular pH near the physiological range similar to those of TASK channels, and was the most active among all K(+) channels. Our results show that in MNCs at rest, eight different types of K(+) channels can be found and six of them belong to the tandem-pore K(+) channel family. Various physiological and pathophysiological conditions may modulate these K(+) channels and regulate the excitability of MNCs.
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