ArticleThe Journal of physiology2003
Maternal protein restriction in the rat impairs resistance artery but not conduit artery function in pregnant offspring.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of low- and high-protein maternal diets during gestation on reproductive outcomes in the rat: a systematic review and meta-analysis.Journal of animal science · 2020Pooled it
- Intrauterine growth restriction weakens anticontractile influence of NO in coronary arteries of adult rats.Scientific reports · 2021Article
- Article
- Near to One's Heart: The Intimate Relationship Between the Placenta and Fetal Heart.Frontiers in physiology · 2018Review
- Long-term effects of maternal undernutrition on offspring carotid artery remodeling: role of miR-29c.Journal of developmental origins of health and disease · 2015Article
- Enhanced mesenteric arterial responsiveness to angiotensin II is androgen receptor-dependent in prenatally protein-restricted adult female rat offspring.Biology of reproduction · 2015Article
- Uteroplacental insufficiency programmes vascular dysfunction in non-pregnant rats: compensatory adaptations in pregnancy.The Journal of physiology · 2012Article
- Protein restriction during pregnancy induces hypertension in adult female rat offspring--influence of oestradiol.The British journal of nutrition · 2012Article
- In utero protein restriction causes growth delay and alters sperm parameters in adult male rats.Reproductive biology and endocrinology : RB&E · 2011Article
- In utero exposure to maternal diabetes impairs vascular expression of prostacyclin receptor in rat offspring.Diabetes · 2010Article
- Uteroplacental insufficiency programs regional vascular dysfunction and alters arterial stiffness in female offspring.The Journal of physiology · 2010Article
- Influence of maternal dysmetabolic conditions during pregnancy on cardiovascular disease.Journal of cardiovascular translational research · 2009Review
- Blastocyst environment and its influence on offspring cardiovascular health: the heart of the matter.Journal of anatomy · 2009Review
- Prenatal cocaine exposure differentially causes vascular dysfunction in adult offspring.Hypertension (Dallas, Tex. : 1979) · 2009Article
- Protein restriction during pregnancy induces hypertension and impairs endothelium-dependent vascular function in adult female offspring.Journal of vascular research · 2009Article
- Endothelial dysfunction and reduced antioxidant protection in an animal model of the developmental origins of cardiovascular disease.The Journal of physiology · 2008Article
- Effect of in utero and early-life conditions on adult health and disease.The New England journal of medicine · 2008Review
- Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring.The Journal of physiology · 2008Article
- Transgenerational effects of prenatal nutrient restriction on cardiovascular and hypothalamic-pituitary-adrenal function.The Journal of physiology · 2008Article
- Mismatched pre- and postnatal nutrition leads to cardiovascular dysfunction and altered renal function in adulthood.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dietary protein restriction during gestation has been shown to produce vascular dysfunction in pregnant rats and hypertension in their offspring. However, no studies have to date examined the effects of such 'programming' on the vascular function of female offspring when they in turn become pregnant. We have therefore studied isolated conduit and resistance artery function from pregnant female offspring of control (C, 18 % casein) and protein-restricted (PR, 9 % casein) pregnant dams. There were no differences in birth weight, weight gain during pregnancy, litter size, fetal weight, placental weight, fetal : placental weight ratio or organ weights between the C and PR groups. In isolated mesenteric arteries, the vasodilatation in response to the endothelial-dependent vasodilator acetylcholine (ACh) and the beta-adrenoceptor agonist isoprenaline was decreased in the PR group, while there were no differences in the constriction in response to potassium (125 mM) or the alpha1-adrenoceptor agonist phenylephrine (PE). No differences in any responses were seen in the isolated thoracic aorta. We conclude that dietary protein restriction in pregnancy programmes vasodilator dysfunction in isolated resistance arteries of female offspring when they become pregnant, but does not affect conduit arteries.
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