ArticleThe Journal of physiology2003
Variation in large-conductance, calcium-activated potassium channels from hair cells along the chicken basilar papilla.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Anatomical and molecular insights into avian inner ear sensory hair cell regeneration.Developmental biology · 2025Review
- Calcium-induced calcium release in proximity to hair cell BK channels revealed by PKA activation.Physiological reports · 2020Article
- Wnt9a Can Influence Cell Fates and Neural Connectivity across the Radial Axis of the Developing Cochlea.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A gradient of Bmp7 specifies the tonotopic axis in the developing inner ear.Nature communications · 2014Article
- Electrical tuning and transduction in short hair cells of the chicken auditory papilla.Journal of neurophysiology · 2013Article
- Hair cell BK channels interact with RACK1, and PKC increases its expression on the cell surface by indirect phosphorylation.American journal of physiology. Cell physiology · 2012Article
- CDK5 interacts with Slo and affects its surface expression and kinetics through direct phosphorylation.American journal of physiology. Cell physiology · 2012Article
- Optimization of gene delivery methods in Xenopus laevis kidney (A6) and Chinese hamster ovary (CHO) cell lines for heterologous expression of Xenopus inner ear genes.In vitro cellular & developmental biology. Animal · 2011Article
- β4-subunit increases Slo responsiveness to physiological Ca2+ concentrations and together with β1 reduces surface expression of Slo in hair cells.American journal of physiology. Cell physiology · 2011Article
- Cholesterol influences voltage-gated calcium channels and BK-type potassium channels in auditory hair cells.PloS one · 2011Article
- Expression of BK-type calcium-activated potassium channel splice variants during chick cochlear development.The Journal of comparative neurology · 2010Article
- Highly specific alternative splicing of transcripts encoding BK channels in the chicken's cochlea is a minor determinant of the tonotopic gradient.Molecular and cellular biology · 2010Article
- Developmental expression of BK channels in chick cochlear hair cells.BMC developmental biology · 2009Article
- The large-conductance Ca(2+)-activated K(+) channel interacts with the apolipoprotein ApoA1.Biochemical and biophysical research communications · 2009Article
- Modulation of the conductance-voltage relationship of the BK(Ca) channel by shortening the cytosolic loop connecting two RCK domains.Biophysical journal · 2009Article
- Tamoxifen inhibits BK channels in chick cochlea without alterations in voltage-dependent activation.American journal of physiology. Cell physiology · 2009Article
- A residue at the cytoplasmic entrance of BK-type channels regulating single-channel opening by its hydrophobicity.Biophysical journal · 2008Article
- The NH2 terminus of RCK1 domain regulates Ca2+-dependent BK(Ca) channel gating.The Journal of general physiology · 2005Article
- BK channel news: full coverage on the calcium bowl.The Journal of general physiology · 2004Article
- A BK (Slo1) channel journey from molecule to physiology.Channels (Austin, Tex.)Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The mechanism for electrical tuning in non-mammalian hair cells rests within the widely diverse kinetics of functionally distinct, large-conductance potassium channels (BK), thought to result from alternative splicing of the pore-forming alpha subunit and variable co-expression with an accessory beta subunit. Inside-out patches from hair cells along the chicken basilar papilla revealed 'tonotopic' gradations in calcium sensitivity and deactivation kinetics. The resonant frequency for the hair cell from which the patch was taken was estimated from deactivation rates, and this frequency reasonably matched that predicted from the originating cell's tonotopic location. The rates of deactivation for native BK channels were much faster than rates reported for cloned chicken BK channels including both alpha and beta subunits. This result was surprising since patches were pulled from hair cells in the apical half of the papilla where beta subunits are most highly expressed. Heterogeneity in the properties of native chicken BK channels implies a high degree of molecular variation and hinders our ability to identify those molecular constituents.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.