ArticleThe Journal of physiology2003
Calcium channel heterogeneity in canine left ventricular myocytes.
Article in The Journal of physiology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 62 citations in OpenAlex.
- Improved CaJournal of molecular and cellular cardiology · 2022Article
- The Effects of Mechanical Preload on Transmural Differences in Mechano-Calcium-Electric Feedback in Single Cardiomyocytes: Experiments and Mathematical Models.Frontiers in physiology · 2020Article
- Transmural gradients in ion channel and auxiliary subunit expression.Progress in biophysics and molecular biology · 2016Review
- The renin-angiotensin system regulates transmural electrical remodeling in response to mechanical load.Progress in biophysics and molecular biology · 2016Review
- Ion Channels in the Heart.Comprehensive Physiology · 2015Review
- Autocrine A2 in the T-system of ventricular myocytes creates transmural gradients in ion transport: a mechanism to match contraction with load?Biophysical journal · 2014Article
- Targeted ablation of the histidine-rich Ca(2+)-binding protein (HRC) gene is associated with abnormal SR Ca(2+)-cycling and severe pathology under pressure-overload stress.Basic research in cardiology · 2013Article
- Blockade of I(Ca) suppresses early afterdepolarizations and reduces transmural dispersion of repolarization in a whole heart model of chronic heart failure.British journal of pharmacology · 2012Article
- Intramural optical mapping of V(m) and Ca(i)2+ during long-duration ventricular fibrillation in canine hearts.American journal of physiology. Heart and circulatory physiology · 2012Article
- Synaptically activated Ca2+ waves and NMDA spikes locally suppress voltage-dependent Ca2+ signalling in rat pyramidal cell dendrites.The Journal of physiology · 2011Article
- GATA-4 promotes myocardial transdifferentiation of mesenchymal stromal cells via up-regulating IGFBP-4.Cytotherapy · 2011Article
- Regional variation in myofilament length-dependent activation.Pflugers Archiv : European journal of physiology · 2011Review
- The mechanisms underlying ICa heterogeneity across murine left ventricle.Molecular and cellular biochemistry · 2011Article
- Transmural heterogeneity of repolarization and Ca2+ handling in a model of mouse ventricular tissue.American journal of physiology. Heart and circulatory physiology · 2010Article
- Electrophysiological remodeling in heart failure.Journal of molecular and cellular cardiology · 2010Review
- Temporal responses to intrinsically coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria during aldosteronism.American journal of physiology. Heart and circulatory physiology · 2010Article
- A transmural gradient in the cardiac Na/K pump generates a transmural gradient in Na/Ca exchange.The Journal of membrane biology · 2010Article
- Mechanisms of transmurally varying myocyte electromechanics in an integrated computational model.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2008Article
- Ca2+/calmodulin-dependent protein kinase II-dependent remodeling of Ca2+ current in pressure overload heart failure.The Journal of biological chemistry · 2008Article
- Drug-induced spatial dispersion of repolarization.Cardiology journal · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Regional variations in the electrophysiological properties of myocytes across the left ventricular wall play an important role in both the normal physiology of the heart and the genesis of arrhythmias. To investigate the possible contributions of calcium channels to transmural electrical heterogeneity, whole-cell patch-clamp recordings were made from isolated canine epicardial and endocardial left ventricular myocytes. Two major differences in Ca2+ channel properties were found between epi- and endocardial cells. First, the L-type Ca2+ current was larger in endocardial than in epicardial myocytes. The average peak current density at +10 mV in endocardial myocytes was 3.4 +/- 0.2 pA pF-1, and was 45 % higher than that in epicardium (2.3 +/- 0.1 pA pF-1). The kinetic properties of the L-type current in epi- and endocardial cells were not significantly different. Second, a low-threshold, rapidly activating and inactivating Ca2+ current that resembled the T-type current was present in all endocardial myocytes but was small or absent in epicardial myocytes. This T-like current had an average peak density of 0.5 pA pF-1 at -40 mV in endocardial cells. In most endocardial cells the T-like Ca2+ current comprised two components: a Ni2+-sensitive T-type current and a tetrodotoxin-sensitive Ca2+ current. We conclude that there are considerable regional variations in the density and properties of Ca2+ channels across the canine left ventricular wall. These variations may contribute to the overall transmural electrical heterogeneity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.