Evidence map›Paper›PMID 12562820›Full record

ArticleJournal of bacteriology2003

The periplasmic protein MppA requires an additional mutated locus to repress marA expression in Escherichia coli.

Xiaowen Bina, Vincent Perreten, Stuart B Levy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 95% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Xiaowen BinaCenter for Adaptation Genetics and Drug Resistance, Tufts University School of Medicine, Boston, Massachusetts 02111, USA.
Vincent Perreten
Stuart B Levy
CNR de la Résistance aux Antibiotiques · FRTufts University · US

Funding

MULTIPLE RESISTANCE TO ANTIBIOTICSR01GM051661 · NIGMS · TUFTS UNIVERSITY BOSTON · PI LEVY, STUART B. · 1994 to 2001
$624k
NIGMS NIH HHS GM51661
6 · The paper itself

Abstract

Escherichia coli strain TP985, which has an insertional mutation in the gene for the periplasmic murein tripeptide binding protein MppA, was previously reported to overproduce MarA and exhibit a multiple-antibiotic resistance (Mar) phenotype (H. Li and J. T. Park, J. Bacteriol. 181:4842-4847, 1999). We found that TP985 contained a previously unrecognized marR mutation which was responsible for the Mar phenotype. Transduction of the mppA mutation from TP985 to another wild-type strain did not affect antibiotic susceptibility. Overproduction of MppA repressed marA transcription in TP985 but not in other mppA or marR mutants. Therefore, TP985 contains an additional unknown mutation(s) that facilitates the repression of marA expression by MppA.

Indexed as

Gene DeletionGene Expression Regulation, BacterialAnti-Bacterial AgentsDNA-Binding ProteinsDrug Resistance, Multiple, BacterialEscherichia coliEscherichia coli ProteinsHumansMembrane Transport ProteinsMicrobial Sensitivity TestsPeriplasmic Binding ProteinsTranscription, GeneticAnti-Bacterial AgentsDNA-Binding ProteinsEscherichia coli ProteinsMarA protein, E coliMembrane Transport ProteinsMppA protein, E coliPeriplasmic Binding Proteins

Identifiers

PMID12562820
PMCPMC142866
OpenAlexW2001596890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.